biostudies-literatureUnknown8(1)Zha LFInterleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457^C-rs2069744^T-rs20541^A) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (p_adj = 0.019 and p_adj = 0.042, respectively). In subgroup popScientific reports6182https://www.ebi.ac.uk/biostudies/studies/S-EPMC5906444biostudies-literatureIL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.PMC5906444Xie TChen QWWang PYDong JTWang FZhang HSZhou YCJiao JCheng XLiao YHTang TTZeng ZPWang QKXia NNie SFXu CQZha LFTu XfalseIL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457^C-rs2069744^T-rs20541^A) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (p_adj = 0.019 and p_adj = 0.042, respectively). In subgroup pop2018-01-01T00:00:00Z2018 Apr2026-04-29T09:38:36.057Z2019-03-26T23:36:10ZS-EPMC59064442967022510.1038/s41598-018-24592-9