{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(3)"],"submitter":["Tsuda B"],"pubmed_abstract":["<h4>Background</h4>Historically, humoral immunity was considered unimportant in anti-tumor immunity, and the differentiation and anti-tumor activity of B cells in breast cancer are poorly understood. However, it was recently discovered that B cells participate in tumor immunity through both antibody production and immunosuppressive mechanisms. We analyzed the expression of B-cell differentiation markers in detail using fluorescence-activated cell sorting to investigate the relationship between B-cell subsets and breast cancer etiology.<h4>Methods</h4>Blood samples were taken from breast cancer patients and healthy donors, and peripheral blood mononuclear cells were collected. B cells at various stages of differentiation were identified by the expression of combinations of the cell surface "],"journal":["Breast cancer (Tokyo, Japan)"],"pagination":["284-291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5906508"],"repository":["biostudies-literature"],"pubmed_title":["B-cell populations are expanded in breast cancer patients compared with healthy controls."],"pmcid":["PMC5906508"],"pubmed_authors":["Miyamoto A","Ogiya R","Terao M","Saito Y","Yokoyama K","Kametani Y","Okamura T","Niikura N","Tokuda Y","Oshitanai R","Suzuki Y","Morioka T","Miyako H","Tsuda B"],"additional_accession":[]},"is_claimable":false,"name":"B-cell populations are expanded in breast cancer patients compared with healthy controls.","description":"<h4>Background</h4>Historically, humoral immunity was considered unimportant in anti-tumor immunity, and the differentiation and anti-tumor activity of B cells in breast cancer are poorly understood. However, it was recently discovered that B cells participate in tumor immunity through both antibody production and immunosuppressive mechanisms. We analyzed the expression of B-cell differentiation markers in detail using fluorescence-activated cell sorting to investigate the relationship between B-cell subsets and breast cancer etiology.<h4>Methods</h4>Blood samples were taken from breast cancer patients and healthy donors, and peripheral blood mononuclear cells were collected. B cells at various stages of differentiation were identified by the expression of combinations of the cell surface ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-05-18T13:10:22.431Z","creation":"2025-05-18T13:10:22.431Z"},"accession":"S-EPMC5906508","cross_references":{"pubmed":["29204848"],"doi":["10.1007/s12282-017-0824-6"]}}