biostudies-literatureWillis ZINIAID NIH HHSNational Institutes of Health339-345https://www.ebi.ac.uk/biostudies/studies/S-EPMC5907874biostudies-literatureUnknown6(4)<h4>Introduction</h4>Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on clinician adherence to program recommendations, but little is known about factors associated with adherence.<h4>Methods</h4>Parenteral antimicrobial-use data for our institution and 43 additional freestanding children's hospitals were obtained and normalized for patient census. Segmental linear regression was used to compare rates of change of parenteral antimicrobial use before and after ASP implementation. Time-series models were developed to predict use in the absenceJournal of the Pediatric Infectious Diseases SocietyReducing Antimicrobial Use in an Academic Pediatric Institution: Evaluation of the Effectiveness of a Prospective Audit With Real-Time Feedback.PMC5907874T32 AI095202Xu MSlaughter JCWillis ZIGillon JDi Pentima MCfalseReducing Antimicrobial Use in an Academic Pediatric Institution: Evaluation of the Effectiveness of a Prospective Audit With Real-Time Feedback.<h4>Introduction</h4>Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on clinician adherence to program recommendations, but little is known about factors associated with adherence.<h4>Methods</h4>Parenteral antimicrobial-use data for our institution and 43 additional freestanding children's hospitals were obtained and normalized for patient census. Segmental linear regression was used to compare rates of change of parenteral antimicrobial use before and after ASP implementation. Time-series models were developed to predict use in the absence2017-01-01T00:00:00Z2017 Nov2025-04-19T00:05:12.633Z2019-03-27T00:08:04ZS-EPMC59078742833959010.1093/jpids/piw054