{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Younis S"],"funding":["Vetenskapsrådet","Carl Tryggers Stiftelse för Vetenskaplig Forskning","Knut och Alice Wallenbergs Stiftelse","Cancerfonden"],"pagination":["E3808-E3816"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5910864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(16)"],"pubmed_abstract":["The zinc finger CCCH-type containing 11A (<i>ZC3H11A</i>) gene encodes a well-conserved zinc finger protein that may function in mRNA export as it has been shown to associate with the transcription export (TREX) complex in proteomic screens. Here, we report that ZC3H11A is a stress-induced nuclear protein with RNA-binding capacity that localizes to nuclear splicing speckles. During an adenovirus infection, the ZC3H11A protein and splicing factor SRSF2 relocalize to nuclear regions where viral DNA replication and transcription take place. Knockout (KO) of <i>ZC3H11A</i> in HeLa cells demonstrated that several nuclear-replicating viruses are dependent on ZC3H11A for efficient growth (HIV, influenza virus, herpes simplex virus, and adenovirus), whereas cytoplasmic replicating viruses are not "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth."],"pmcid":["PMC5910864"],"funding_grant_id":["K2015-57-21980-04-4","Project:LA","130469","CTS17:111"],"pubmed_authors":["Andersson L","Falkeborn T","Akusjarvi G","Hinkula J","Yu D","Essand M","Wang H","Kamel W","Daniels R","Younis S"],"additional_accession":[]},"is_claimable":false,"name":"Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.","description":"The zinc finger CCCH-type containing 11A (<i>ZC3H11A</i>) gene encodes a well-conserved zinc finger protein that may function in mRNA export as it has been shown to associate with the transcription export (TREX) complex in proteomic screens. Here, we report that ZC3H11A is a stress-induced nuclear protein with RNA-binding capacity that localizes to nuclear splicing speckles. During an adenovirus infection, the ZC3H11A protein and splicing factor SRSF2 relocalize to nuclear regions where viral DNA replication and transcription take place. Knockout (KO) of <i>ZC3H11A</i> in HeLa cells demonstrated that several nuclear-replicating viruses are dependent on ZC3H11A for efficient growth (HIV, influenza virus, herpes simplex virus, and adenovirus), whereas cytoplasmic replicating viruses are not ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-05-04T09:22:52.162Z","creation":"2019-03-26T23:43:23Z"},"accession":"S-EPMC5910864","cross_references":{"pubmed":["29610341"],"doi":["10.1073/pnas.1722333115"]}}