{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rong-Mullins X"],"funding":["NHGRI NIH HHS"],"pagination":["607-619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5919752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["Cellular metabolism can change the potency of a chemical's tumorigenicity. 4-nitroquinoline-1-oxide (4NQO) is a tumorigenic drug widely used on animal models for cancer research. Polymorphisms of the transcription factor Yrr1 confer different levels of resistance to 4NQO in <i>Saccharomyces cerevisiae</i> To study how different Yrr1 alleles regulate gene expression leading to resistance, transcriptomes of three isogenic <i>S</i><i>cerevisiae</i> strains carrying different Yrr1 alleles were profiled via RNA sequencing (RNA-Seq) and chromatin immunoprecipitation coupled with sequencing (ChIP-Seq) in the presence and absence of 4NQO. In response to 4NQO, all alleles of Yrr1 drove the expression of <i>SNQ2</i> (a multidrug transporter), which was highest in the presence of 4NQO resistance-conf"],"journal":["G3 (Bethesda, Md.)"],"pubmed_title":["Transcriptional Profiling of <i>Saccharomyces cerevisiae</i> Reveals the Impact of Variation of a Single Transcription Factor on Differential Gene Expression in 4NQO, Fermentable, and Nonfermentable Carbon Sources."],"pmcid":["PMC5919752"],"funding_grant_id":["T32 HG000044"],"pubmed_authors":["Summers M","Rong-Mullins X","Ayers MC","Gallagher JEG"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional Profiling of <i>Saccharomyces cerevisiae</i> Reveals the Impact of Variation of a Single Transcription Factor on Differential Gene Expression in 4NQO, Fermentable, and Nonfermentable Carbon Sources.","description":"Cellular metabolism can change the potency of a chemical's tumorigenicity. 4-nitroquinoline-1-oxide (4NQO) is a tumorigenic drug widely used on animal models for cancer research. Polymorphisms of the transcription factor Yrr1 confer different levels of resistance to 4NQO in <i>Saccharomyces cerevisiae</i> To study how different Yrr1 alleles regulate gene expression leading to resistance, transcriptomes of three isogenic <i>S</i><i>cerevisiae</i> strains carrying different Yrr1 alleles were profiled via RNA sequencing (RNA-Seq) and chromatin immunoprecipitation coupled with sequencing (ChIP-Seq) in the presence and absence of 4NQO. In response to 4NQO, all alleles of Yrr1 drove the expression of <i>SNQ2</i> (a multidrug transporter), which was highest in the presence of 4NQO resistance-conf","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-05-01T19:45:10.363Z","creation":"2019-03-26T23:33:47Z"},"accession":"S-EPMC5919752","cross_references":{"pubmed":["29208650"],"doi":["10.1534/g3.117.300138"]}}