{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagamani SCS"],"funding":["NICHD NIH HHS","NIGMS NIH HHS"],"pagination":["708-716"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5924481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(7)"],"pubmed_abstract":["<h4>Purpose</h4>Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.<h4>Methods</h4>We conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m<sup>-2</sup>BSA•day<sup>-1</sup>), benzoate (NaBz; 5.5 g•m<sup>-2</sup>BSA•day<sup>-1</sup>), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m<sup>-2</sup>BSA•day<sup>-1</sup>) on nitrogen excretion. Stable isotopes were used to study effects on urea production and dietary nitrogen disposal.<h4>Results</h4>The conjugation efficacy for both phenylbutyrate and benzoate was 65%; conjugation w"],"journal":["Genetics in medicine : official journal of the American College of Medical Genetics"],"pubmed_title":["A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers."],"pmcid":["PMC5924481"],"funding_grant_id":["R03 HD078447","U54 HD083092","U54 HD061221","T32 GM007526"],"pubmed_authors":["Didelija IC","Nagamani SCS","McMeans A","Agarwal U","Mohammad MA","Marini JC","Tam A","Azamian M"],"additional_accession":[]},"is_claimable":false,"name":"A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers.","description":"<h4>Purpose</h4>Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.<h4>Methods</h4>We conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m<sup>-2</sup>BSA•day<sup>-1</sup>), benzoate (NaBz; 5.5 g•m<sup>-2</sup>BSA•day<sup>-1</sup>), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m<sup>-2</sup>BSA•day<sup>-1</sup>) on nitrogen excretion. Stable isotopes were used to study effects on urea production and dietary nitrogen disposal.<h4>Results</h4>The conjugation efficacy for both phenylbutyrate and benzoate was 65%; conjugation w","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2026-05-05T23:07:27.675Z","creation":"2019-03-26T23:52:11Z"},"accession":"S-EPMC5924481","cross_references":{"pubmed":["29693650"],"doi":["10.1038/gim.2017.167"]}}