biostudies-literatureNagamani SCSNICHD NIH HHSNIGMS NIH HHS708-716https://www.ebi.ac.uk/biostudies/studies/S-EPMC5924481biostudies-literatureUnknown20(7)<h4>Purpose</h4>Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.<h4>Methods</h4>We conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m^-2BSA•day^-1), benzoate (NaBz; 5.5 g•m^-2BSA•day^-1), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m^-2BSA•day^-1) on nitrogen excretion. Stable isotopes were used to study effects on urea production and dietary nitrogen disposal.<h4>Results</h4>The conjugation efficacy for both phenylbutyrate and benzoate was 65%; conjugation wGenetics in medicine : official journal of the American College of Medical GeneticsA randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers.PMC5924481R03 HD078447U54 HD083092U54 HD061221T32 GM007526Didelija ICNagamani SCSMcMeans AAgarwal UMohammad MAMarini JCTam AAzamian MfalseA randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers.<h4>Purpose</h4>Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.<h4>Methods</h4>We conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m^-2BSA•day^-1), benzoate (NaBz; 5.5 g•m^-2BSA•day^-1), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m^-2BSA•day^-1) on nitrogen excretion. Stable isotopes were used to study effects on urea production and dietary nitrogen disposal.<h4>Results</h4>The conjugation efficacy for both phenylbutyrate and benzoate was 65%; conjugation w2018-01-01T00:00:00Z2018 Jul2026-05-05T23:07:27.675Z2019-03-26T23:52:11ZS-EPMC59244812969365010.1038/gim.2017.167