biostudies-literatureUnknown98(1)Olotu AEquatorial Guinea (EG) has implemented a successful malaria control program on Bioko Island. A highly effective vaccine would be an ideal complement to this effort and could lead to halting transmission and eliminating malaria. Sanaria^® PfSPZ Vaccine (<i>Plasmodium falciparum</i> sporozoite Vaccine) is being developed for this purpose. To begin the process of establishing the efficacy of and implementing a PfSPZ Vaccine mass vaccination program in EG, we decided to conduct a series of clinical trials of PfSPZ Vaccine on Bioko Island. Because no clinical trial had ever been conducted in EG, we first successfully established the ethical, regulatory, quality, and clinical foundation for conducting trials. We now report the safety, tolerability, and immunogenicity results of the firThe American journal of tropical medicine and hygiene308-318https://www.ebi.ac.uk/biostudies/studies/S-EPMC5928718biostudies-literatureAdvancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men.PMC5928718Lee Sim BKRivas MRDaubenberger CKc NAyekaba MOMaas CDSchwabe CMandumbi DOHamad AAbdulla SMilang DNNyakarungu ERuben AJHoffman SLBillingsley PFEburi ESaverino EOlotu AMurshedkar TEmbon OMChemba MAbebe YSchindler TLi MRaso JSegura JLAdams MHergott DEka MTanner MUrbano VChakravarty SRichie TLJames ERManoj AfalseAdvancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men.Equatorial Guinea (EG) has implemented a successful malaria control program on Bioko Island. A highly effective vaccine would be an ideal complement to this effort and could lead to halting transmission and eliminating malaria. Sanaria^® PfSPZ Vaccine (<i>Plasmodium falciparum</i> sporozoite Vaccine) is being developed for this purpose. To begin the process of establishing the efficacy of and implementing a PfSPZ Vaccine mass vaccination program in EG, we decided to conduct a series of clinical trials of PfSPZ Vaccine on Bioko Island. Because no clinical trial had ever been conducted in EG, we first successfully established the ethical, regulatory, quality, and clinical foundation for conducting trials. We now report the safety, tolerability, and immunogenicity results of the fir2018-01-01T00:00:00Z2018 Jan2025-04-04T13:59:45.228Z2019-03-26T23:34:42ZS-EPMC59287182914173910.4269/ajtmh.17-0449