{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(28)"],"submitter":["Nesheim N"],"pubmed_abstract":["Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is associated with urinary tract symptoms and hormonal imbalances amongst others. The heterogeneous clinical presentation, unexplored molecular background and lack of prostate biopsies complicate therapy. Here, using liquid biopsies, we performed a comprehensive translational study on men diagnosed with CP/CPPS type III (<i>n</i><b><i>=</i></b> 50; median age 39.8, range 23-65) and age-matched controls (<i>n</i><b><i>=</i></b> 61; median age 36.8, range 20-69), considering biochemical parameters of blood and ejaculates, and epigenetic regulation of the estrogen receptor genes (<i>ESR1</i> and <i>ESR2</i>) in leukocytes isolated from blood (systemic regulation) and in somatic cells isolated from ejaculates (local regulation). We fou"],"journal":["Oncotarget"],"pagination":["19623-19639"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5929413"],"repository":["biostudies-literature"],"pubmed_title":["Elevated seminal plasma estradiol and epigenetic inactivation of <i>ESR1</i> and <i>ESR2</i> is associated with CP/CPPS."],"pmcid":["PMC5929413"],"pubmed_authors":["Pilatz A","Weidner W","Schuppe HC","Dansranjavin T","Berg E","Schagdarsurengin U","Ellem S","Schambeck R","Risbridger G","Nesheim N","Wagenlehner F","Hagenkotter C"],"additional_accession":[]},"is_claimable":false,"name":"Elevated seminal plasma estradiol and epigenetic inactivation of <i>ESR1</i> and <i>ESR2</i> is associated with CP/CPPS.","description":"Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is associated with urinary tract symptoms and hormonal imbalances amongst others. The heterogeneous clinical presentation, unexplored molecular background and lack of prostate biopsies complicate therapy. Here, using liquid biopsies, we performed a comprehensive translational study on men diagnosed with CP/CPPS type III (<i>n</i><b><i>=</i></b> 50; median age 39.8, range 23-65) and age-matched controls (<i>n</i><b><i>=</i></b> 61; median age 36.8, range 20-69), considering biochemical parameters of blood and ejaculates, and epigenetic regulation of the estrogen receptor genes (<i>ESR1</i> and <i>ESR2</i>) in leukocytes isolated from blood (systemic regulation) and in somatic cells isolated from ejaculates (local regulation). We fou","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-07-15T21:17:20.207Z","creation":"2025-06-01T12:39:30.016Z"},"accession":"S-EPMC5929413","cross_references":{"pubmed":["29731970"],"doi":["10.18632/oncotarget.24714"]}}