biostudies-literatureDixon-Suen SCCancer Research UKNCATS NIH HHSNCRR NIH HHSMedical Research CouncilNCI NIH HHS1123-1129https://www.ebi.ac.uk/biostudies/studies/S-EPMC5931085biostudies-literatureUnknown118(8)<h4>Background</h4>Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.<h4>Methods</h4>We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.<h4>Results</h4>Greater genetically predicted height was associated with increased ovarian cancer risk overBritish journal of cancerAdult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.PMC5931085C5047/A10692MR/R026017/1P30 CA008748P50 CA159981UL1 TR001881U19 CA148537R03 CA113148C12292/A11174C1287/A10118C1281/A12014C8197/A16565R01 CA12244310119R01 CA063678K07 CA143047P50 CA105009U19 CA148065C536/A6689M01 RR000056K07 CA095666R01 CA095023R01 CA11252316561R03 CA115195UL1 TR000124C1287/A 10710C490/A16561K22 CA138563P30 CA072720R01 CA063682R01 CA069044C536/A13086C1312/A15589C5047/A8384P30 CA016056N01 CN025403P50 CA136393U19 CA148112R01 CA05886010124C5047/A15007Heitz FDork TSouthey MCJung AYSieh WLubinski JHogdall CKPhelan CLiang DBjorge LGronwald JOdunsi KHildebrandt MATThomsen LCVGentry-Maharaj ASalvesen HBLundvall LShvetsov YBBogdanova NZheng WKelemen LEOrsulic SHillemanns PLester JModugno FBruegl APearce CLRzepecka IKKarlan BYNagle CMGayther SALevine DATyrer JPLu KHBisogna MDansonka-Mieszkowska AVan Nieuwenhuysen ESchildkraut JMZiogas ALambrechts SRimel BJPelttari LMDixon-Suen SCHuzarski TGoodman MTWilkens LRNarod SANess RBLambrechts DWicklund KGHogdall EWentzensen NWhittemore ASRisch HAWu AHdu Bois ARossing MASiddiqui NPaul JSwenerton KDWebb PMPharoah PDPKopperud RKPike MCHarter PWinham SJMenkiszak JChenevix-Trench GWu XBudzilowska AYang HThrift APKiemeney LAMilne RLChang-Claude JAustralian Ovarian Cancer Study GroupTseng CCOvarian Cancer Association ConsortiumKupryjanczyk JFasching PASchwaab IEccles DNevanlinna HThompson PJLeminen ABrooks-Wilson AKjær SKBerchuck ALe NDAnton-Culver HTerry KLCook LSDoherty JABandera EVOlson SHPejovic TJensen AMenon UBeckmann MWGiles GGRamus SJCunningham JMMassuger LFAGMcLaughlin JRPark-Simon TWKelley JLCramer DWMcGuire VEwing AMoysich KBVergote IEdwards RPSong HBrinton LCampbell IGlasspool RRothstein JHButzow RFridley BLLissowska JBruinsma FGoode ELfalseAdult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.<h4>Background</h4>Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.<h4>Methods</h4>We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.<h4>Results</h4>Greater genetically predicted height was associated with increased ovarian cancer risk over2018-01-01T00:00:00Z2018 Apr2026-05-04T22:57:36.785Z2026-04-07T21:08:57.305ZS-EPMC59310852955599010.1038/s41416-018-0011-3