{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coristine AJ"],"funding":["Swiss National Science Foundation","NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["1293-1303"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5931377"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(3)"],"pubmed_abstract":["<h4>Purpose</h4>In respiratory self-navigation (SN), signal from static structures, such as the chest wall, may complicate motion detection or introduce post-correction artefacts. Suppressing signal from superfluous tissues may therefore improve image quality. We thus test the hypothesis that SN whole-heart coronary magnetic resonance angiography (MRA) will benefit from an outer-volume suppressing 2D-T<sub>2</sub> -Prep and present both phantom and in vivo results.<h4>Methods</h4>A 2D-T<sub>2</sub> -Prep and a conventional T<sub>2</sub> -Prep were used prior to a free-breathing 3D-radial SN sequence. Both techniques were compared by imaging a home-built moving cardiac phantom and by performing coronary MRA in nine healthy volunteers. Reconstructions were performed using both a reference-based and a reference-independent approach to motion tracking, along with several coil combinations. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were compared, along with vessel sharpness (VS).<h4>Results</h4>In phantoms, using the 2D-T<sub>2</sub> -Prep increased SNR by 16% to 53% and mean VS by 8%; improved motion tracking precision was also achieved. In volunteers, SNR increased by an average of 29% to 33% in the blood pool and by 15% to 25% in the myocardium, depending on the choice of reconstruction coils and algorithm, and VS increased by 34%.<h4>Conclusion</h4>A 2D-T<sub>2</sub> -Prep significantly improves image quality in both phantoms and volunteers when performing SN coronary MRA. Magn Reson Med 79:1293-1303, 2018. © 2017 International Society for Magnetic Resonance in Medicine."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Improved respiratory self-navigation for 3D radial acquisitions through the use of a pencil-beam 2D-T<sub>2</sub> -prep for free-breathing, whole-heart coronary MRA."],"pmcid":["PMC5931377"],"funding_grant_id":["320030","326030_150828","R01 DK098503","P2LAP3_164909","R01 HL094557","PZ00P3‐154719","320030_143923","164909"],"pubmed_authors":["Stuber M","Ginami G","Chaptinel J","Bonanno G","Coristine AJ","Coppo S","van Heeswijk RB","Piccini D"],"additional_accession":[]},"is_claimable":false,"name":"Improved respiratory self-navigation for 3D radial acquisitions through the use of a pencil-beam 2D-T<sub>2</sub> -prep for free-breathing, whole-heart coronary MRA.","description":"<h4>Purpose</h4>In respiratory self-navigation (SN), signal from static structures, such as the chest wall, may complicate motion detection or introduce post-correction artefacts. Suppressing signal from superfluous tissues may therefore improve image quality. We thus test the hypothesis that SN whole-heart coronary magnetic resonance angiography (MRA) will benefit from an outer-volume suppressing 2D-T<sub>2</sub> -Prep and present both phantom and in vivo results.<h4>Methods</h4>A 2D-T<sub>2</sub> -Prep and a conventional T<sub>2</sub> -Prep were used prior to a free-breathing 3D-radial SN sequence. Both techniques were compared by imaging a home-built moving cardiac phantom and by performing coronary MRA in nine healthy volunteers. Reconstructions were performed using both a reference-based and a reference-independent approach to motion tracking, along with several coil combinations. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were compared, along with vessel sharpness (VS).<h4>Results</h4>In phantoms, using the 2D-T<sub>2</sub> -Prep increased SNR by 16% to 53% and mean VS by 8%; improved motion tracking precision was also achieved. In volunteers, SNR increased by an average of 29% to 33% in the blood pool and by 15% to 25% in the myocardium, depending on the choice of reconstruction coils and algorithm, and VS increased by 34%.<h4>Conclusion</h4>A 2D-T<sub>2</sub> -Prep significantly improves image quality in both phantoms and volunteers when performing SN coronary MRA. Magn Reson Med 79:1293-1303, 2018. © 2017 International Society for Magnetic Resonance in Medicine.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2024-11-12T23:53:58.528Z","creation":"2019-08-03T07:23:26Z"},"accession":"S-EPMC5931377","cross_references":{"pubmed":["28568961"],"doi":["10.1002/mrm.26764"]}}