{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Orozco LD"],"funding":["NIDDK NIH HHS","Howard Hughes Medical Institute","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","NIAMS NIH HHS","NIH","NIGMS NIH HHS"],"pagination":["1830-1846"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5932563"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(10)"],"pubmed_abstract":["Most epigenome-wide association studies to date have been conducted in blood. However, metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to study adipose tissue in order to understand the effects of this syndrome on epigenomes. To determine if natural variation in DNA methylation was associated with metabolic syndrome traits, we profiled global methylation levels in subcutaneous abdominal adipose tissue. We measured association between 32 clinical traits related to diabetes and obesity in 201 people from the Metabolic Syndrome in Men cohort. We performed epigenome-wide association studies between DNA methylation levels and traits, and identified associations for 13 clinical traits in 21 loci. We prioritized candidate genes in these loci using expre"],"journal":["Human molecular genetics"],"pubmed_title":["Epigenome-wide association in adipose tissue from the METSIM cohort."],"pmcid":["PMC5932563"],"funding_grant_id":["P01 HL030568","T32 AR059033","P30 CA016042","P30 DK020572","U01 DK062370","HL30568 and 1P50 GM115318","HL28481","P01 HL028481","P50 CA211015","P50 GM115318","R01 DK093757"],"pubmed_authors":["Pellegrini M","Seldin M","Rubbi L","Kuusisto J","Boehnke M","Orozco LD","Hale C","Rinaldi A","Farrell C","Civelek M","Pan C","Edillor C","Lam L","Lusis AJ","Mohlke KL","Laakso M","Montoya D","Jacobsen S"],"additional_accession":[]},"is_claimable":false,"name":"Epigenome-wide association in adipose tissue from the METSIM cohort.","description":"Most epigenome-wide association studies to date have been conducted in blood. However, metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to study adipose tissue in order to understand the effects of this syndrome on epigenomes. To determine if natural variation in DNA methylation was associated with metabolic syndrome traits, we profiled global methylation levels in subcutaneous abdominal adipose tissue. We measured association between 32 clinical traits related to diabetes and obesity in 201 people from the Metabolic Syndrome in Men cohort. We performed epigenome-wide association studies between DNA methylation levels and traits, and identified associations for 13 clinical traits in 21 loci. We prioritized candidate genes in these loci using expre","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-04-08T13:53:00.732Z","creation":"2019-06-06T23:03:22Z"},"accession":"S-EPMC5932563","cross_references":{"pubmed":["29566149"],"doi":["10.1093/hmg/ddy093"]}}