biostudies-literatureChen YLGuangdong Medical Scientific Research FoundationNatural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of ChinaKey Program of Young Teachers Foundation of Sun Yat-sen University81https://www.ebi.ac.uk/biostudies/studies/S-EPMC5932798biostudies-literatureUnknown20(1)<h4>Background</h4>Previous studies have revealed that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA), while there are no further clinical studies regarding the role of HBV infection in RA progression during disease-modifying anti-rheumatic drug (DMARD) therapy. Here, we aimed to explore the influence of HBV infection on radiographic and clinical outcomes among patients with RA in a clinical practice setting.<h4>Methods</h4>Thirty-two consecutive patients with RA (Disease Activity Score 28-joint assessment based on C-reactive protein (DAS28-CRP) ≥2.6) with chronic HBV infection (CHB) were retrospectively recruited as the CHB group and 128 age-matched, sex-matched, and disease activity-matched contemporary patients with RA without CHB were included in theArthritis research & therapyDeleterious role of hepatitis B virus infection in therapeutic response among patients with rheumatoid arthritis in a clinical practice setting: a case-control study.PMC59327982016A03031330717ykjc1281471597816716122017A030313576A2017109816014272014A030313074Yang ZHDai LLin JZLi QHMo YQYan TZheng DHChen YLMa JDWang XYfalseDeleterious role of hepatitis B virus infection in therapeutic response among patients with rheumatoid arthritis in a clinical practice setting: a case-control study.<h4>Background</h4>Previous studies have revealed that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA), while there are no further clinical studies regarding the role of HBV infection in RA progression during disease-modifying anti-rheumatic drug (DMARD) therapy. Here, we aimed to explore the influence of HBV infection on radiographic and clinical outcomes among patients with RA in a clinical practice setting.<h4>Methods</h4>Thirty-two consecutive patients with RA (Disease Activity Score 28-joint assessment based on C-reactive protein (DAS28-CRP) ≥2.6) with chronic HBV infection (CHB) were retrospectively recruited as the CHB group and 128 age-matched, sex-matched, and disease activity-matched contemporary patients with RA without CHB were included in the2018-01-01T00:00:00Z2018 May2025-05-29T21:21:42.003Z2025-05-29T21:21:42.003ZS-EPMC59327982972022110.1186/s13075-018-1548-5