{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moeini S"],"funding":["Sharif University of Technology","Iran National Science Foundation"],"pagination":["146-155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5935180"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(3)"],"pubmed_abstract":["The interest in biodegradable polymer-matrix nanocomposites with bone regeneration potential has been increasing in recent years. In the present work, a solvothermal process is introduced to prepare hydroxyapatite (HA) nanorod-reinforced polycaprolactone <i>in-situ</i>. A non-aqueous polymer solution containing calcium and phosphorous precursors is prepared and processed in a closed autoclave at different temperatures in the range of 60-150 °C. Hydroxyapatite nanorods with varying aspect ratios are formed depending on the processing temperature. X-ray diffraction analysis and field-emission scanning electron microscopy indicate that the HA nanorods are semi-crystalline. Energy-dispersive X-ray spectroscopy and Fourier transform infrared spectrometry determine that the ratio of calcium to p"],"journal":["Bioactive materials"],"pubmed_title":["<i>In-situ</i> solvothermal processing of polycaprolactone/hydroxyapatite nanocomposites with enhanced mechanical and biological performance for bone tissue engineering."],"pmcid":["PMC5935180"],"funding_grant_id":["95-S-48740","G930305"],"pubmed_authors":["Mohammadi MR","Moeini S","Simchi A"],"additional_accession":[]},"is_claimable":false,"name":"<i>In-situ</i> solvothermal processing of polycaprolactone/hydroxyapatite nanocomposites with enhanced mechanical and biological performance for bone tissue engineering.","description":"The interest in biodegradable polymer-matrix nanocomposites with bone regeneration potential has been increasing in recent years. In the present work, a solvothermal process is introduced to prepare hydroxyapatite (HA) nanorod-reinforced polycaprolactone <i>in-situ</i>. A non-aqueous polymer solution containing calcium and phosphorous precursors is prepared and processed in a closed autoclave at different temperatures in the range of 60-150 °C. Hydroxyapatite nanorods with varying aspect ratios are formed depending on the processing temperature. X-ray diffraction analysis and field-emission scanning electron microscopy indicate that the HA nanorods are semi-crystalline. Energy-dispersive X-ray spectroscopy and Fourier transform infrared spectrometry determine that the ratio of calcium to p","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-05-29T21:52:06.927Z","creation":"2025-05-29T21:52:06.927Z"},"accession":"S-EPMC5935180","cross_references":{"pubmed":["29744424"],"doi":["10.1016/j.bioactmat.2017.04.004"]}}