{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hobson BA"],"funding":["NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["170-178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5940565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66"],"pubmed_abstract":["Current treatments for seizures induced by organophosphates do not protect sufficiently against progressive neurodegeneration or delayed cognitive impairment. Developing more effective therapeutic approaches has been challenging because the pathogenesis of these delayed consequences is poorly defined. Using magnetic resonance imaging (MRI), we previously reported brain lesions that persist for months in a rat model of acute intoxication with the OP, diisopropylfluorophosphate (DFP). However, the early spatiotemporal progression of these lesions remains unknown. To address this data gap, we used in vivo MRI to longitudinally monitor brain lesions during the first 3 d following acute DFP intoxication. Adult male Sprague Dawley rats acutely intoxicated with DFP (4mg/kg, sc) were MR imaged at "],"journal":["Neurotoxicology"],"pubmed_title":["A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication."],"pmcid":["PMC5940565"],"funding_grant_id":["T32 GM099608","U54 NS079202"],"pubmed_authors":["Rowland DJ","Supasai S","Lein PJ","Garbow JR","Hobson BA","Harvey DJ"],"additional_accession":[]},"is_claimable":false,"name":"A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.","description":"Current treatments for seizures induced by organophosphates do not protect sufficiently against progressive neurodegeneration or delayed cognitive impairment. Developing more effective therapeutic approaches has been challenging because the pathogenesis of these delayed consequences is poorly defined. Using magnetic resonance imaging (MRI), we previously reported brain lesions that persist for months in a rat model of acute intoxication with the OP, diisopropylfluorophosphate (DFP). However, the early spatiotemporal progression of these lesions remains unknown. To address this data gap, we used in vivo MRI to longitudinally monitor brain lesions during the first 3 d following acute DFP intoxication. Adult male Sprague Dawley rats acutely intoxicated with DFP (4mg/kg, sc) were MR imaged at ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-04T01:26:49.066Z","creation":"2019-06-06T22:51:55Z"},"accession":"S-EPMC5940565","cross_references":{"pubmed":["29183789"],"doi":["10.1016/j.neuro.2017.11.009"]}}