{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang H"],"funding":["NIH HHS","NIGMS NIH HHS"],"pagination":["1815"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5940903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2-G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-posit"],"journal":["Nature communications"],"pubmed_title":["Supramolecular Kandinsky circles with high antibacterial activity."],"pmcid":["PMC5940903"],"funding_grant_id":["R01 GM128037","1R01GM128037-01"],"pubmed_authors":["Haoyang WW","Hao XQ","Su M","Cai J","Wang H","Brzozowski R","Eswara P","Wang K","Gong W","Qian X","Wang M","Li X","Li Y","Xu B","Jiang X","Hou JL","Gao X"],"additional_accession":[]},"is_claimable":false,"name":"Supramolecular Kandinsky circles with high antibacterial activity.","description":"Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2-G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-posit","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-05T10:58:26.781Z","creation":"2019-03-26T23:36:53Z"},"accession":"S-EPMC5940903","cross_references":{"pubmed":["29739936"],"doi":["10.1038/s41467-018-04247-z"]}}