biostudies-literatureRodriguez-Garcia MNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSNCI NIH HHSNational Institutes of HealthNIGMS NIH HHSe12733https://www.ebi.ac.uk/biostudies/studies/S-EPMC5946085biostudies-literatureUnknown17(3)As women age, susceptibility to systemic and genital infections increases. Tissue-resident memory T cells (TRMs) are CD103⁺ CD8⁺ long-lived lymphocytes that provide critical mucosal immune protection. Mucosal dendritic cells (DCs) are known to induce CD103 expression on CD8⁺ T cells. While CD103⁺ CD8⁺ T cells are found throughout the female reproductive tract (FRT), the extent to which aging impacts their presence and induction by DCs remains unknown. Using hysterectomy tissues, we found that endometrial CD103⁺ CD8⁺ T cells were increased in postmenopausal compared to premenopausal women. Endometrial DCs from postmenopausal women were significantly more effective at inducing CD103 expression on allogeneic naïve CDAging cellAging impacts CD103⁺ CD8⁺ T cell presence and induction by dendritic cells in the genital tract.PMC5946085P30 CA023108AI117739R01 AI117739P30 GM103415AI102838R01 AI102838Wira CRFortier JMBarr FDRodriguez-Garcia MfalseAging impacts CD103⁺ CD8⁺ T cell presence and induction by dendritic cells in the genital tract.As women age, susceptibility to systemic and genital infections increases. Tissue-resident memory T cells (TRMs) are CD103⁺ CD8⁺ long-lived lymphocytes that provide critical mucosal immune protection. Mucosal dendritic cells (DCs) are known to induce CD103 expression on CD8⁺ T cells. While CD103⁺ CD8⁺ T cells are found throughout the female reproductive tract (FRT), the extent to which aging impacts their presence and induction by DCs remains unknown. Using hysterectomy tissues, we found that endometrial CD103⁺ CD8⁺ T cells were increased in postmenopausal compared to premenopausal women. Endometrial DCs from postmenopausal women were significantly more effective at inducing CD103 expression on allogeneic naïve CD2018-01-01T00:00:00Z2018 Jun2025-04-22T09:52:14.229Z2019-03-26T23:54:31ZS-EPMC59460852945547410.1111/acel.12733