{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Varghese RT"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","National Institutes of Health"],"pagination":["549-555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5946313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["Aims
To compare the performance of population-based kinetics with that of directly measured C-peptide kinetics when used to calculate β-cell responsivity indices, and to study people with and without acute insulin resistance to ensure that population-based kinetics apply to all conditions where β-cell function is measured.Methods
Somatostatin was used to inhibit endogenous insulin secretion in 56 people without diabetes. Subsequently, a C-peptide bolus was administered and the changing concentrations were used to calculate individual kinetic measures of C-peptide clearance. In addition, the participants were studied on 2 occasions in random order using an oral glucose tolerance test (OGTT). On one occasion, free fatty acid elevation, to cause insulin resistance, was achieve"],"journal":["Diabetes, obesity & metabolism"],"pubmed_title":["Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance."],"pmcid":["PMC5946313"],"funding_grant_id":["5T32 DK007352-37","T32 DK007352","UL1 TR000135","R01 DK078646","R01 DK78646"],"pubmed_authors":["Shah M","Cobelli C","Dalla Man C","Sharma A","Laurenti MC","Rizza RA","Bailey KR","Vella A","Varghese RT","Piccinini F"],"additional_accession":[]},"is_claimable":false,"name":"Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance.","description":"Aims
To compare the performance of population-based kinetics with that of directly measured C-peptide kinetics when used to calculate β-cell responsivity indices, and to study people with and without acute insulin resistance to ensure that population-based kinetics apply to all conditions where β-cell function is measured.Methods
Somatostatin was used to inhibit endogenous insulin secretion in 56 people without diabetes. Subsequently, a C-peptide bolus was administered and the changing concentrations were used to calculate individual kinetic measures of C-peptide clearance. In addition, the participants were studied on 2 occasions in random order using an oral glucose tolerance test (OGTT). On one occasion, free fatty acid elevation, to cause insulin resistance, was achieve","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-05T15:06:59.757Z","creation":"2019-06-06T19:29:39Z"},"accession":"S-EPMC5946313","cross_references":{"pubmed":["28862812"],"doi":["10.1111/dom.13106"]}}