{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pelissier Vatter FA"],"funding":["Swiss National Science Foundation","Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","European Research Council","Norges ForskningsrÃ¥d","NIA NIH HHS","NIDDK NIH HHS","Universitetet i Bergen","Helse Vest","Seventh Framework Programme","Universität Zürich","NCI NIH HHS","National Institutes of Health"],"pagination":["1205-1219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5946804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(4)"],"pubmed_abstract":["Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished tumor-suppressive cell types and the accumulation of defective epithelial progenitors. Quantitative characterization of these age-emergent human cell subpopulations is lacking, impeding our understanding of the relationship between age and cancer susceptibility. We conducted single-cell resolution proteomic phenotyping of healthy breast epithelia from 57 women, aged 16-91 years, using mass cytometry. Remarkable heterogeneity was quantified within the two mammary epithelial lineages. Population partitioning identified a subset of aberrant basal-like luminal cells that accum"],"journal":["Cell reports"],"pubmed_title":["High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia."],"pmcid":["PMC5946804"],"funding_grant_id":["BC141351","240130","R00 AG033176","316030-139220","316030","PP00P3-144874","P30 CA033572","R00AG033176","336921","BIOEF-17-001","FK-74419-01-01","223250","911794","R01AG040081","144874","UC4 DK108132","FP/2007-2013","R01 AG040081","139220"],"pubmed_authors":["LaBarge MA","Stampfer MR","Borowsky AD","Lee JK","Pelissier Vatter FA","Schapiro D","Bodenmiller B","Lorens JB","Chang H","Parvin B"],"additional_accession":[]},"is_claimable":false,"name":"High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia.","description":"Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished tumor-suppressive cell types and the accumulation of defective epithelial progenitors. Quantitative characterization of these age-emergent human cell subpopulations is lacking, impeding our understanding of the relationship between age and cancer susceptibility. We conducted single-cell resolution proteomic phenotyping of healthy breast epithelia from 57 women, aged 16-91 years, using mass cytometry. Remarkable heterogeneity was quantified within the two mammary epithelial lineages. Population partitioning identified a subset of aberrant basal-like luminal cells that accum","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-05-06T06:37:10.02Z","creation":"2019-03-26T23:37:18Z"},"accession":"S-EPMC5946804","cross_references":{"pubmed":["29694896"],"doi":["10.1016/j.celrep.2018.03.114"]}}