{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Austin HP"],"funding":["US Department of Energy","Sao Paulo Research Foundation","Biotechnology and Biological Sciences Research Council","NREL"],"pagination":["E4350-E4357"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5948967"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(19)"],"pubmed_abstract":["Poly(ethylene terephthalate) (PET) is one of the most abundantly produced synthetic polymers and is accumulating in the environment at a staggering rate as discarded packaging and textiles. The properties that make PET so useful also endow it with an alarming resistance to biodegradation, likely lasting centuries in the environment. Our collective reliance on PET and other plastics means that this buildup will continue unless solutions are found. Recently, a newly discovered bacterium, <i>Ideonella sakaiensis</i> 201-F6, was shown to exhibit the rare ability to grow on PET as a major carbon and energy source. Central to its PET biodegradation capability is a secreted PETase (PET-digesting enzyme). Here, we present a 0.92 Å resolution X-ray crystal structure of PETase, which reveals feature"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Characterization and engineering of a plastic-degrading aromatic polyesterase."],"pmcid":["PMC5948967"],"funding_grant_id":["BB/P011918/1","#2016/22956-7","LDRD","DE-SC0011297TDD"],"pubmed_authors":["Silveira RL","El Omari K","Mykhaylyk V","Duman R","Skaf MS","Rorrer NA","Woodcock HL","Austin HP","Thorne AW","McGeehan JE","Amore A","Pollard BC","Dominick G","Allen MD","Johnson CW","Donohoe BS","Beckham GT","Wagner A","Crowley MF","Kearns FL","Michener WE"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and engineering of a plastic-degrading aromatic polyesterase.","description":"Poly(ethylene terephthalate) (PET) is one of the most abundantly produced synthetic polymers and is accumulating in the environment at a staggering rate as discarded packaging and textiles. The properties that make PET so useful also endow it with an alarming resistance to biodegradation, likely lasting centuries in the environment. Our collective reliance on PET and other plastics means that this buildup will continue unless solutions are found. Recently, a newly discovered bacterium, <i>Ideonella sakaiensis</i> 201-F6, was shown to exhibit the rare ability to grow on PET as a major carbon and energy source. Central to its PET biodegradation capability is a secreted PETase (PET-digesting enzyme). Here, we present a 0.92 Å resolution X-ray crystal structure of PETase, which reveals feature","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-04-17T19:25:35.784Z","creation":"2019-03-26T23:44:47Z"},"accession":"S-EPMC5948967","cross_references":{"pubmed":["29666242"],"doi":["10.1073/pnas.1718804115"]}}