{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shalaby KH"],"funding":["Intramural NIH HHS","NULL"],"pagination":["1229-1242.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5951733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["142(4)"],"pubmed_abstract":["<h4>Background</h4>Mechanisms that elicit mucosal T<sub>H</sub>17 cell responses have been described, yet how these cells are sustained in chronically inflamed tissues remains unclear.<h4>Objective</h4>We sought to understand whether maintenance of lung T<sub>H</sub>17 inflammation requires environmental agents in addition to antigen and to identify the lung antigen-presenting cell (APC) types that sustain the self-renewal of T<sub>H</sub>17 cells.<h4>Methods</h4>Animals were exposed repeatedly to aspiration of ovalbumin alone or together with environmental adjuvants, including common house dust extract (HDE), to test their role in maintaining lung inflammation. Alternatively, antigen-specific effector/memory T<sub>H</sub>17 cells, generated in culture with CD4<sup>+</sup> T cells from Il1"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Pathogenic T&lt;sub&gt;H&lt;/sub&gt;17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling."],"pmcid":["PMC5951733"],"funding_grant_id":["ZIA ES102025-09","Z01 ES102025","ZIA ES102025"],"pubmed_authors":["Lyons-Cohen MR","Whitehead GS","Shalaby KH","Prinz I","Cook DN","Nakano H","Thomas SY"],"additional_accession":[]},"is_claimable":false,"name":"Pathogenic T&lt;sub&gt;H&lt;/sub&gt;17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling.","description":"<h4>Background</h4>Mechanisms that elicit mucosal T<sub>H</sub>17 cell responses have been described, yet how these cells are sustained in chronically inflamed tissues remains unclear.<h4>Objective</h4>We sought to understand whether maintenance of lung T<sub>H</sub>17 inflammation requires environmental agents in addition to antigen and to identify the lung antigen-presenting cell (APC) types that sustain the self-renewal of T<sub>H</sub>17 cells.<h4>Methods</h4>Animals were exposed repeatedly to aspiration of ovalbumin alone or together with environmental adjuvants, including common house dust extract (HDE), to test their role in maintaining lung inflammation. Alternatively, antigen-specific effector/memory T<sub>H</sub>17 cells, generated in culture with CD4<sup>+</sup> T cells from Il1","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-04-13T07:15:37.633Z","creation":"2019-03-26T23:59:40Z"},"accession":"S-EPMC5951733","cross_references":{"pubmed":["29154958"],"doi":["10.1016/j.jaci.2017.10.023"]}}