biostudies-literatureUnknown9(1)Yu MThe development of a spectroscopy device on a chip that could realize real-time fingerprinting with label-free and high-throughput detection of trace molecules represents one of the big challenges in sensing. Dual-comb spectroscopy (DCS) in the mid-infrared is a powerful technique offering high acquisition rates and signal-to-noise ratios through use of only a single detector with no moving parts. Here, we present a nanophotonic silicon-on-insulator platform designed for mid-infrared (mid-IR) DCS. A single continuous-wave low-power pump source generates two mutually coherent mode-locked frequency combs spanning from 2.6 to 4.1 μm in two silicon microresonators. A proof-of-principle experiment of vibrational absorption DCS in the liquid phase is achieved acquiring spectra of acetone spanninNature communications1869https://www.ebi.ac.uk/biostudies/studies/S-EPMC5951801biostudies-literatureSilicon-chip-based mid-infrared dual-comb spectroscopy.PMC5951801Griffith AGYu MLipson MOkawachi YGaeta ALPicque NfalseSilicon-chip-based mid-infrared dual-comb spectroscopy.The development of a spectroscopy device on a chip that could realize real-time fingerprinting with label-free and high-throughput detection of trace molecules represents one of the big challenges in sensing. Dual-comb spectroscopy (DCS) in the mid-infrared is a powerful technique offering high acquisition rates and signal-to-noise ratios through use of only a single detector with no moving parts. Here, we present a nanophotonic silicon-on-insulator platform designed for mid-infrared (mid-IR) DCS. A single continuous-wave low-power pump source generates two mutually coherent mode-locked frequency combs spanning from 2.6 to 4.1 μm in two silicon microresonators. A proof-of-principle experiment of vibrational absorption DCS in the liquid phase is achieved acquiring spectra of acetone spannin2018-01-01T00:00:00Z2018 May2025-04-04T22:42:58.923Z2019-03-26T23:37:28ZS-EPMC59518012976041810.1038/s41467-018-04350-1