{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu R"],"funding":["Postgraduate Research & Practice Innovation Program of Jiangsu Province","China Agriculture Research System","National Natural Science Foundation of China","Natural Science Foundation of Jiangsu Province, China"],"pagination":["388-400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5953243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research found that NADPH oxidase-silenced strains exhibited a partial reduction in the response to SA, resulting in the induction of increased ROS production. Furthermore, the localization of ROS shows that mitochondria are sources of ROS production in response to SA treatment. An additional analysis focused on the relationship between SA-induced ROS production and mitochondrial functions, and the results showed that inhibitors of mitochondrial complexes I and II exert approximately 40-"],"journal":["Redox biology"],"pubmed_title":["SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum."],"pmcid":["PMC5953243"],"funding_grant_id":["31672212","BK20171377","KYZZ16_0383","81773839"],"pubmed_authors":["Shi L","Zhu J","Wang S","Jiang AL","Liu R","Cao P","Yang T","Zhao MW","Zhu T","Ren A"],"additional_accession":[]},"is_claimable":false,"name":"SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum.","description":"Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research found that NADPH oxidase-silenced strains exhibited a partial reduction in the response to SA, resulting in the induction of increased ROS production. Furthermore, the localization of ROS shows that mitochondria are sources of ROS production in response to SA treatment. An additional analysis focused on the relationship between SA-induced ROS production and mitochondrial functions, and the results showed that inhibitors of mitochondrial complexes I and II exert approximately 40-","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-05T14:35:52.502Z","creation":"2019-03-26T23:37:30Z"},"accession":"S-EPMC5953243","cross_references":{"pubmed":["29631100"],"doi":["10.1016/j.redox.2018.03.018"]}}