{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["122(10)"],"submitter":["Zhang Y"],"pubmed_abstract":["<h4>Rationale</h4>Ca<sup>2+</sup> homeostasis-a critical determinant of cardiac contractile function-is critically regulated by SERCA2a (sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase 2a). Our previous study has identified <i>ZFAS1</i> as a new lncRNA biomarker of acute myocardial infarction (MI).<h4>Objective</h4>To evaluate the effects of <i>ZFAS1</i> on SERCA2a and the associated Ca<sup>2+</sup> homeostasis and cardiac contractile function in the setting of MI.<h4>Methods and results</h4><i>ZFAS1</i> expression was robustly increased in cytoplasm and sarcoplasmic reticulum in a mouse model of MI and a cellular model of hypoxia. Knockdown of endogenous <i>ZFAS1</i> by virus-mediated silencing shRNA partially abrogated the ischemia-induced contractile dysfunction. Overexpression of <i>ZFAS"],"journal":["Circulation research"],"pagination":["1354-1368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5959220"],"repository":["biostudies-literature"],"pubmed_title":["LncRNA <i>ZFAS1</i> as a SERCA2a Inhibitor to Cause Intracellular Ca<sup>2+</sup> Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction."],"pmcid":["PMC5959220"],"pubmed_authors":["Jiao L","Pan Z","Li C","Lu Y","Xu C","Li Q","Yang B","Li M","Zhuang Y","Sun L","Li Y","Shao Y","Zhang Y","Gao Y","Yang R","Xuan L"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA <i>ZFAS1</i> as a SERCA2a Inhibitor to Cause Intracellular Ca<sup>2+</sup> Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.","description":"<h4>Rationale</h4>Ca<sup>2+</sup> homeostasis-a critical determinant of cardiac contractile function-is critically regulated by SERCA2a (sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase 2a). Our previous study has identified <i>ZFAS1</i> as a new lncRNA biomarker of acute myocardial infarction (MI).<h4>Objective</h4>To evaluate the effects of <i>ZFAS1</i> on SERCA2a and the associated Ca<sup>2+</sup> homeostasis and cardiac contractile function in the setting of MI.<h4>Methods and results</h4><i>ZFAS1</i> expression was robustly increased in cytoplasm and sarcoplasmic reticulum in a mouse model of MI and a cellular model of hypoxia. Knockdown of endogenous <i>ZFAS1</i> by virus-mediated silencing shRNA partially abrogated the ischemia-induced contractile dysfunction. Overexpression of <i>ZFAS","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-06-14T06:12:37.481Z","creation":"2026-06-14T03:16:08.79Z"},"accession":"S-EPMC5959220","cross_references":{"pubmed":["29475982"],"doi":["10.1161/CIRCRESAHA.117.312117"]}}