{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krukowski K"],"funding":["NIA NIH HHS"],"pagination":["7857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5959907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation. The repopulated microglia present a modified functional phenotype with reduced expression of scavenger receptors, lysosome membrane protein and complement receptor, all sho"],"journal":["Scientific reports"],"pubmed_title":["Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits."],"pmcid":["PMC5959907"],"funding_grant_id":["F32 AG054126"],"pubmed_authors":["Nelson G","Krukowski K","Grue K","Riparip LK","Feng X","Paladini MS","Rosi S","Campbell-Beachler M","Chou A","Sacramento K","Jones T"],"additional_accession":[]},"is_claimable":false,"name":"Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits.","description":"Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation. The repopulated microglia present a modified functional phenotype with reduced expression of scavenger receptors, lysosome membrane protein and complement receptor, all sho","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-04T14:01:33.922Z","creation":"2019-03-26T23:44:15Z"},"accession":"S-EPMC5959907","cross_references":{"pubmed":["29777152"],"doi":["10.1038/s41598-018-26039-7"]}}