{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Um SW"],"funding":["National R&amp;D program for cancer control, Ministry of Health &amp; Welfare, Republic of Korea"],"pagination":["65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5960087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Background:The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation. Methods:DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 hospital-based controls using Illumina HumanMethylation450K BeadChip. Methylation levels in these bronchial washings were compared to those in 897 primary lung tissues of The Cancer Genome Atlas (TCGA) data. Results:Twenty-four CpGs (p < 1.03E-07) were significantly methylated in bronchial washings from 70 NSCLC patients compared to those from 53 controls. The CpGs also had significant methylation in the TCGA cohort. The 123 participants were divided into a training set (N = 82)"],"journal":["Clinical epigenetics"],"pubmed_title":["Genome-wide analysis of DNA methylation in bronchial washings."],"pmcid":["PMC5960087"],"funding_grant_id":["1520150"],"pubmed_authors":["Kim DH","Kim D","Kim HK","Um SW","Kim H","Lee BB","Kim Y","Han J","Lee KJ","Shim YM"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analysis of DNA methylation in bronchial washings.","description":"Background:The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation. Methods:DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 hospital-based controls using Illumina HumanMethylation450K BeadChip. Methylation levels in these bronchial washings were compared to those in 897 primary lung tissues of The Cancer Genome Atlas (TCGA) data. Results:Twenty-four CpGs (p < 1.03E-07) were significantly methylated in bronchial washings from 70 NSCLC patients compared to those from 53 controls. The CpGs also had significant methylation in the TCGA cohort. The 123 participants were divided into a training set (N = 82)","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-04T14:01:57.733Z","creation":"2019-03-26T23:39:17Z"},"accession":"S-EPMC5960087","cross_references":{"pubmed":["29796116"],"doi":["10.1186/s13148-018-0498-8"]}}