{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Ludke A"],"pubmed_abstract":["Animals can form associations between temporally separated stimuli. To do so, the nervous system has to retain a neural representation of the first stimulus until the second stimulus appears. The neural substrate of such sensory stimulus memories is unknown. Here, we search for a sensory odor memory in the insect olfactory system and characterize odorant-evoked Ca2+ activity at three consecutive layers of the olfactory system in Drosophila: in olfactory receptor neurons (ORNs) and projection neurons (PNs) in the antennal lobe, and in Kenyon cells (KCs) in the mushroom body. We show that the post-stimulus responses in ORN axons, PN dendrites, PN somata, and KC dendrites are odor-specific, but they are not predictive of the chemical identity of past olfactory stimuli. However, the post-stimulus responses in KC somata carry information about the identity of previous olfactory stimuli. These findings show that the Ca2+ dynamics in KC somata could encode a sensory memory of odorant identity and thus might serve as a basis for associations between temporally separated stimuli."],"journal":["Frontiers in cellular neuroscience"],"pagination":["128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5960692"],"repository":["biostudies-literature"],"pubmed_title":["Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory in Drosophila."],"pmcid":["PMC5960692"],"pubmed_authors":["Raiser G","Nehrkorn J","Herz AVM","Galizia CG","Ludke A","Szyszka P"],"additional_accession":[]},"is_claimable":false,"name":"Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory in Drosophila.","description":"Animals can form associations between temporally separated stimuli. To do so, the nervous system has to retain a neural representation of the first stimulus until the second stimulus appears. The neural substrate of such sensory stimulus memories is unknown. Here, we search for a sensory odor memory in the insect olfactory system and characterize odorant-evoked Ca2+ activity at three consecutive layers of the olfactory system in Drosophila: in olfactory receptor neurons (ORNs) and projection neurons (PNs) in the antennal lobe, and in Kenyon cells (KCs) in the mushroom body. We show that the post-stimulus responses in ORN axons, PN dendrites, PN somata, and KC dendrites are odor-specific, but they are not predictive of the chemical identity of past olfactory stimuli. However, the post-stimulus responses in KC somata carry information about the identity of previous olfactory stimuli. These findings show that the Ca2+ dynamics in KC somata could encode a sensory memory of odorant identity and thus might serve as a basis for associations between temporally separated stimuli.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2020-11-22T11:51:31Z","creation":"2019-03-26T23:46:33Z"},"accession":"S-EPMC5960692","cross_references":{"pubmed":["29867361"],"doi":["10.3389/fncel.2018.00128"]}}