{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Z"],"funding":["NCCIH NIH HHS","NIDA NIH HHS","Beijing University of Chinese Medicine","Foundation for the National Institutes of Health","NIMH NIH HHS","National Natural Science Foundation of China"],"pagination":["195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5962703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Identification of biological markers for defining subtypes of major depressive disorder (MDD) is critical for better understanding MDD pathophysiology and finding effective treatment intervention. The \"<i>Yin</i> and <i>Yang</i>\" theory is a fundamental concept of traditional Chinese Medicine (TCM). The theory differentiates MDD patients into two subtypes, <i>Yin</i> and <i>Yang</i>, based on their somatic symptoms, which had empirically been used for the delivery of effective treatment in East Asia. Nonetheless, neural processes underlying <i>Yin</i> and <i>Yang</i> types in MDD are poorly understood. In this study, we aim to provide physiological evidence using functional magnetic resonance imaging (fMRI) to identify altered resting-state brain activity associated with <i>Yin</i> and <i>"],"journal":["Frontiers in psychiatry"],"pubmed_title":["Altered Resting-State Brain Activities in Drug-Naive Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by <i>Yin</i>-<i>Yang</i> Theory of the Traditional Chinese Medicine."],"pmcid":["PMC5962703"],"funding_grant_id":["R01 DA041208","DA-041208","81573905","P50 MH094268","2015-JYB-XS199","AT008547","P50MH094268","R21 AT008547"],"pubmed_authors":["Kuga H","Zhao Q","Wang D","Qu M","Zhou D","Zhu X","Huang L","Zeng Y","Zhang S","Xu Z","Kamiya A"],"additional_accession":[]},"is_claimable":false,"name":"Altered Resting-State Brain Activities in Drug-Naive Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by <i>Yin</i>-<i>Yang</i> Theory of the Traditional Chinese Medicine.","description":"Identification of biological markers for defining subtypes of major depressive disorder (MDD) is critical for better understanding MDD pathophysiology and finding effective treatment intervention. The \"<i>Yin</i> and <i>Yang</i>\" theory is a fundamental concept of traditional Chinese Medicine (TCM). The theory differentiates MDD patients into two subtypes, <i>Yin</i> and <i>Yang</i>, based on their somatic symptoms, which had empirically been used for the delivery of effective treatment in East Asia. Nonetheless, neural processes underlying <i>Yin</i> and <i>Yang</i> types in MDD are poorly understood. In this study, we aim to provide physiological evidence using functional magnetic resonance imaging (fMRI) to identify altered resting-state brain activity associated with <i>Yin</i> and <i>","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-05T16:04:13.178Z","creation":"2019-03-26T23:40:30Z"},"accession":"S-EPMC5962703","cross_references":{"pubmed":["29867614"],"doi":["10.3389/fpsyt.2018.00195"]}}