biostudies-literatureXu ZNCCIH NIH HHSNIDA NIH HHSBeijing University of Chinese MedicineFoundation for the National Institutes of HealthNIMH NIH HHSNational Natural Science Foundation of China195https://www.ebi.ac.uk/biostudies/studies/S-EPMC5962703biostudies-literatureUnknown9Identification of biological markers for defining subtypes of major depressive disorder (MDD) is critical for better understanding MDD pathophysiology and finding effective treatment intervention. The "<i>Yin</i> and <i>Yang</i>" theory is a fundamental concept of traditional Chinese Medicine (TCM). The theory differentiates MDD patients into two subtypes, <i>Yin</i> and <i>Yang</i>, based on their somatic symptoms, which had empirically been used for the delivery of effective treatment in East Asia. Nonetheless, neural processes underlying <i>Yin</i> and <i>Yang</i> types in MDD are poorly understood. In this study, we aim to provide physiological evidence using functional magnetic resonance imaging (fMRI) to identify altered resting-state brain activity associated with <i>Yin</i> and <i>Frontiers in psychiatryAltered Resting-State Brain Activities in Drug-Naive Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by <i>Yin</i>-<i>Yang</i> Theory of the Traditional Chinese Medicine.PMC5962703R01 DA041208DA-04120881573905P50 MH0942682015-JYB-XS199AT008547P50MH094268R21 AT008547Kuga HZhao QWang DQu MZhou DZhu XHuang LZeng YZhang SXu ZKamiya AfalseAltered Resting-State Brain Activities in Drug-Naive Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by <i>Yin</i>-<i>Yang</i> Theory of the Traditional Chinese Medicine.Identification of biological markers for defining subtypes of major depressive disorder (MDD) is critical for better understanding MDD pathophysiology and finding effective treatment intervention. The "<i>Yin</i> and <i>Yang</i>" theory is a fundamental concept of traditional Chinese Medicine (TCM). The theory differentiates MDD patients into two subtypes, <i>Yin</i> and <i>Yang</i>, based on their somatic symptoms, which had empirically been used for the delivery of effective treatment in East Asia. Nonetheless, neural processes underlying <i>Yin</i> and <i>Yang</i> types in MDD are poorly understood. In this study, we aim to provide physiological evidence using functional magnetic resonance imaging (fMRI) to identify altered resting-state brain activity associated with <i>Yin</i> and <i>2018-01-01T00:00:00Z20182025-04-05T16:04:13.178Z2019-03-26T23:40:30ZS-EPMC59627032986761410.3389/fpsyt.2018.00195