{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["365(11)"],"submitter":["Cranford-Smith T"],"funding":["Biotechnology and Biological Sciences Research Council"],"pubmed_abstract":["In bacteria, translocation of most soluble secreted proteins (and outer membrane proteins in Gram-negative bacteria) across the cytoplasmic membrane by the Sec machinery is mediated by the essential ATPase SecA. At its core, this machinery consists of SecA and the integral membrane proteins SecYEG, which form a protein conducting channel in the membrane. Proteins are recognised by the Sec machinery by virtue of an internally encoded targeting signal, which usually takes the form of an N-terminal signal sequence. In addition, substrate proteins must be maintained in an unfolded conformation in the cytoplasm, prior to translocation, in order to be competent for translocation through SecYEG. Recognition of substrate proteins occurs via SecA-either through direct recognition by SecA or through"],"journal":["FEMS microbiology letters"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5963308"],"repository":["biostudies-literature"],"pubmed_title":["The way is the goal: how SecA transports proteins across the cytoplasmic membrane in bacteria."],"pmcid":["PMC5963308"],"funding_grant_id":["BB/L019434/1"],"pubmed_authors":["Cranford-Smith T","Huber D"],"additional_accession":[]},"is_claimable":false,"name":"The way is the goal: how SecA transports proteins across the cytoplasmic membrane in bacteria.","description":"In bacteria, translocation of most soluble secreted proteins (and outer membrane proteins in Gram-negative bacteria) across the cytoplasmic membrane by the Sec machinery is mediated by the essential ATPase SecA. At its core, this machinery consists of SecA and the integral membrane proteins SecYEG, which form a protein conducting channel in the membrane. Proteins are recognised by the Sec machinery by virtue of an internally encoded targeting signal, which usually takes the form of an N-terminal signal sequence. In addition, substrate proteins must be maintained in an unfolded conformation in the cytoplasm, prior to translocation, in order to be competent for translocation through SecYEG. Recognition of substrate proteins occurs via SecA-either through direct recognition by SecA or through","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-06-01T12:39:17.672Z","creation":"2025-06-01T12:39:17.672Z"},"accession":"S-EPMC5963308","cross_references":{"pubmed":["29790985"],"doi":["10.1093/femsle/fny093"]}}