{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["West C"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NIH HHS"],"pagination":["e1007020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5963806"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["The fruit fly Drosophila melanogaster is a powerful model system for the study of innate immunity in vector insects as well as mammals. For vector insects, it is particularly important to understand all aspects of their antiviral immune defenses, which could eventually be harnessed to control the transmission of human pathogenic viruses. The immune responses controlling RNA viruses in insects have been extensively studied, but the response to DNA virus infections is poorly characterized. Here, we report that infection of Drosophila with the DNA virus Invertebrate iridescent Virus 6 (IIV-6) triggers JAK-STAT signaling and the robust expression of the Turandots, a gene family encoding small secreted proteins. To drive JAK-STAT signaling, IIV-6 infection more immediately induced expression of"],"journal":["PLoS pathogens"],"pubmed_title":["p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila."],"pmcid":["PMC5963806"],"funding_grant_id":["R01 060025","T32 AI095213","R01 AI060025","R21 AI131695","RO1 AI060025","T32 AI007349"],"pubmed_authors":["Silverman N","West C"],"additional_accession":[]},"is_claimable":false,"name":"p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila.","description":"The fruit fly Drosophila melanogaster is a powerful model system for the study of innate immunity in vector insects as well as mammals. For vector insects, it is particularly important to understand all aspects of their antiviral immune defenses, which could eventually be harnessed to control the transmission of human pathogenic viruses. The immune responses controlling RNA viruses in insects have been extensively studied, but the response to DNA virus infections is poorly characterized. Here, we report that infection of Drosophila with the DNA virus Invertebrate iridescent Virus 6 (IIV-6) triggers JAK-STAT signaling and the robust expression of the Turandots, a gene family encoding small secreted proteins. To drive JAK-STAT signaling, IIV-6 infection more immediately induced expression of","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-05-30T00:53:50.812Z","creation":"2026-04-08T06:30:39.927Z"},"accession":"S-EPMC5963806","cross_references":{"pubmed":["29746571"],"doi":["10.1371/journal.ppat.1007020"]}}