{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheah HY"],"funding":["Malaysian Ministry of Higher Education’s HIR-MoHE grants","PPP grant, University of Malaya, Malaysia","Ministry of Education, Science and Technological Development, Republic of Serbia","Malaysian Ministry of Higher Education’s HIR-MoHE","University of Malaya","Ministry of Education, Science and Technological Development of the Republic of Serbia"],"pagination":["210-222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5964453"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Conjugation of Doxorubicin (DOX) to N-(2-hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX. Rats implanted with radio-telemetry device were administered intravenously with DOX (5 mg/kg), HPMA-DOX (5 mg DOX equivalent/kg) and HPMA copolymer and subjected to continuous cardiovascular monitoring and echoc"],"journal":["Nanotoxicology"],"pubmed_title":["Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats."],"pmcid":["PMC5964453"],"funding_grant_id":["III 41013","UM.C/625/1/HIR/MOHE/MED/33","PG024-2015A","UM.C/625/1/HIR/MOHE/MED/17,UM.C/625/1/HIR/MOHE/MED/33","UM.C/625/1/HIR/MOHE/MED/17","III41013"],"pubmed_authors":["Hindmarch CC","Sarenac O","Lee HB","Japundzic-Zigon N","Vasic M","Murphy D","Arroyo JJ","Hoe SZ","Lozic M","Glumac S","Cheah HY","Kiew LV","Vicent MJ","Chung LY"],"additional_accession":[]},"is_claimable":false,"name":"Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats.","description":"Conjugation of Doxorubicin (DOX) to N-(2-hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX. Rats implanted with radio-telemetry device were administered intravenously with DOX (5 mg/kg), HPMA-DOX (5 mg DOX equivalent/kg) and HPMA copolymer and subjected to continuous cardiovascular monitoring and echoc","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2025-04-05T10:58:37.593Z","creation":"2019-03-26T23:39:51Z"},"accession":"S-EPMC5964453","cross_references":{"pubmed":["28098511"],"doi":["10.1080/17435390.2017.1285071"]}}