biostudies-literatureCheah HYMalaysian Ministry of Higher Education’s HIR-MoHE grantsPPP grant, University of Malaya, MalaysiaMinistry of Education, Science and Technological Development, Republic of SerbiaMalaysian Ministry of Higher Education’s HIR-MoHEUniversity of MalayaMinistry of Education, Science and Technological Development of the Republic of Serbia210-222https://www.ebi.ac.uk/biostudies/studies/S-EPMC5964453biostudies-literatureUnknown11(2)Conjugation of Doxorubicin (DOX) to N-(2-hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX. Rats implanted with radio-telemetry device were administered intravenously with DOX (5 mg/kg), HPMA-DOX (5 mg DOX equivalent/kg) and HPMA copolymer and subjected to continuous cardiovascular monitoring and echocNanotoxicologyHemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats.PMC5964453III 41013UM.C/625/1/HIR/MOHE/MED/33PG024-2015AUM.C/625/1/HIR/MOHE/MED/17,UM.C/625/1/HIR/MOHE/MED/33UM.C/625/1/HIR/MOHE/MED/17III41013Hindmarch CCSarenac OLee HBJapundzic-Zigon NVasic MMurphy DArroyo JJHoe SZLozic MGlumac SCheah HYKiew LVVicent MJChung LYfalseHemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats.Conjugation of Doxorubicin (DOX) to N-(2-hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX. Rats implanted with radio-telemetry device were administered intravenously with DOX (5 mg/kg), HPMA-DOX (5 mg DOX equivalent/kg) and HPMA copolymer and subjected to continuous cardiovascular monitoring and echoc2017-01-01T00:00:00Z2017 Mar2025-04-05T10:58:37.593Z2019-03-26T23:39:51ZS-EPMC59644532809851110.1080/17435390.2017.1285071