{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geng J"],"funding":["Ministry of Science and Technology","Ministry of Science and Technology (ROC)","Chang Gung Memorial Hospital, Linkou"],"pagination":["386"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5966866"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
Streptococcus salivarius is an abundant isolate of the human oral microbiota. Since both pH and glucose availability fluctuate frequently in the oral cavity, the goal of this study was to investigate regulation by CodY, a conserved pleiotropic regulator of Gram positive bacteria, in response to these two signals. The chemostat culture system was employed to precisely control the growth parameters, and the transcriptomes of wild-type S. salivarius 57.I and its CodY-null derivative (ΔcodY) grown at pH 7 and 5.5, with limited and excessive glucose supply were determined.Results
The transcriptomic analysis revealed that CodY was most active at pH 7 under conditions of glucose limitation. Based on whether a CodY binding consensus could be located in the 5' flanking re"],"journal":["BMC genomics"],"pubmed_title":["Impact of growth pH and glucose concentrations on the CodY regulatory network in Streptococcus salivarius."],"pmcid":["PMC5966866"],"funding_grant_id":["CMRPD1G0151","MOST 105-2320-B-182-015-MY3"],"pubmed_authors":["Huang SC","Chiu CH","Hu S","Chen YY","Geng J","Chen YM"],"additional_accession":[]},"is_claimable":false,"name":"Impact of growth pH and glucose concentrations on the CodY regulatory network in Streptococcus salivarius.","description":"Background
Streptococcus salivarius is an abundant isolate of the human oral microbiota. Since both pH and glucose availability fluctuate frequently in the oral cavity, the goal of this study was to investigate regulation by CodY, a conserved pleiotropic regulator of Gram positive bacteria, in response to these two signals. The chemostat culture system was employed to precisely control the growth parameters, and the transcriptomes of wild-type S. salivarius 57.I and its CodY-null derivative (ΔcodY) grown at pH 7 and 5.5, with limited and excessive glucose supply were determined.Results
The transcriptomic analysis revealed that CodY was most active at pH 7 under conditions of glucose limitation. Based on whether a CodY binding consensus could be located in the 5' flanking re","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-04-29T22:31:16.663Z","creation":"2019-03-26T23:39:25Z"},"accession":"S-EPMC5966866","cross_references":{"pubmed":["29792173"],"doi":["10.1186/s12864-018-4781-z"]}}