{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Ventura-Bixenshpaner H"],"pubmed_abstract":["Acquired resistance to the estrogen receptor (ER) antagonist tamoxifen, is a major obstacle in treatment of breast cancer. Changes in Zn<sup>2+</sup> accumulation and distribution are associated with tamoxifen-resistance and breast cancer progression. The Zn<sup>2+</sup>-sensing G-protein coupled receptor, ZnR/GPR39, triggers signaling leading to cell growth, but a role for this receptor in breast cancer in unknown. Using fluorescence imaging, we found Zn<sup>2+</sup>-dependent Ca<sup>2+</sup> release, mediated by ZnR/GPR39 activity, in TAMR tamoxifen-resistant cells derived from MCF-7 cells, but not in ER-expressing MCF-7 or T47D cells. Furthermore, ZnR/GPR39 signaling was monitored in ER negative BT20, MDA-MB-453 and JIMT-1 cells. Expression of ZnR/GPR39 was increased in grade 3 human br"],"journal":["Scientific reports"],"pagination":["8119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5970167"],"repository":["biostudies-literature"],"pubmed_title":["Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth."],"pmcid":["PMC5970167"],"pubmed_authors":["Sekler I","Elkabets M","Asraf H","Taylor KM","Ventura-Bixenshpaner H","Chakraborty M","Hershfinkel M"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.","description":"Acquired resistance to the estrogen receptor (ER) antagonist tamoxifen, is a major obstacle in treatment of breast cancer. Changes in Zn<sup>2+</sup> accumulation and distribution are associated with tamoxifen-resistance and breast cancer progression. The Zn<sup>2+</sup>-sensing G-protein coupled receptor, ZnR/GPR39, triggers signaling leading to cell growth, but a role for this receptor in breast cancer in unknown. Using fluorescence imaging, we found Zn<sup>2+</sup>-dependent Ca<sup>2+</sup> release, mediated by ZnR/GPR39 activity, in TAMR tamoxifen-resistant cells derived from MCF-7 cells, but not in ER-expressing MCF-7 or T47D cells. Furthermore, ZnR/GPR39 signaling was monitored in ER negative BT20, MDA-MB-453 and JIMT-1 cells. Expression of ZnR/GPR39 was increased in grade 3 human br","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-07-15T17:02:13.812Z","creation":"2019-03-26T23:39:30Z"},"accession":"S-EPMC5970167","cross_references":{"pubmed":["29802348"],"doi":["10.1038/s41598-018-26459-5"]}}