{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei L"],"funding":["Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","Research Manitoba","Gouvernement du Canada | Canadian Institutes of Health Research"],"pagination":["e00651-17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5974433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(12)"],"pubmed_abstract":["The pituitary-derived somatolactotrophe GH<sub>3</sub> cells secrete both growth hormone (GH) and prolactin (PRL). We have found that the hnRNP L and L-like (LL) paralogs differentially regulate alternative splicing of genes in these cells. Here, we show that hnRNP L is essential for PRL only, but LL is essential for both PRL and GH production. Transcriptome-wide RNA sequencing (RNA-Seq) analysis indicates that they differentially control groups of hormone or hormone-related genes involved in hormone production/regulation at total transcript and alternative exon levels. Interestingly, hnRNP L also specifically binds and prevents the aberrant usage of a nonconserved CA-rich intron piece of <i>Prl</i> pre-mRNA transcripts, and many others involved in endocrine functions, to prevent mostly cr"],"journal":["Molecular and cellular biology"],"pubmed_title":["Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells."],"pmcid":["PMC5974433"],"funding_grant_id":["RGPIN-2016-06004","FRN106608","Chair Fund"],"pubmed_authors":["Sohail M","Lei L","Liu L","Cao W","Das U","Xie J","Chen Y","Wu Y","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells.","description":"The pituitary-derived somatolactotrophe GH<sub>3</sub> cells secrete both growth hormone (GH) and prolactin (PRL). We have found that the hnRNP L and L-like (LL) paralogs differentially regulate alternative splicing of genes in these cells. Here, we show that hnRNP L is essential for PRL only, but LL is essential for both PRL and GH production. Transcriptome-wide RNA sequencing (RNA-Seq) analysis indicates that they differentially control groups of hormone or hormone-related genes involved in hormone production/regulation at total transcript and alternative exon levels. Interestingly, hnRNP L also specifically binds and prevents the aberrant usage of a nonconserved CA-rich intron piece of <i>Prl</i> pre-mRNA transcripts, and many others involved in endocrine functions, to prevent mostly cr","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2026-04-30T09:48:59.985Z","creation":"2019-03-26T23:39:37Z"},"accession":"S-EPMC5974433","cross_references":{"pubmed":["29610151"],"doi":["10.1128/MCB.00651-17"]}}