{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(5)"],"submitter":["Krajnovic T"],"funding":["German Academic Exchange Service (DAAD)","Ministry of Education, Science and Technological Development of the Republic of Serbia"],"pubmed_abstract":["In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionall"],"journal":["Nanomaterials (Basel, Switzerland)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5977336"],"repository":["biostudies-literature"],"pubmed_title":["Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15."],"pmcid":["PMC5977336"],"funding_grant_id":["57219021","173013"],"pubmed_authors":["Draca D","Kaluđerovic GN","Krajnovic T","Maksimovic-Ivanic D","Wessjohann LA","Mijatovic S","Wolf K","Edeler D"],"additional_accession":[]},"is_claimable":false,"name":"Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15.","description":"In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionall","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-21T19:30:57.212Z","creation":"2019-03-26T23:39:59Z"},"accession":"S-EPMC5977336","cross_references":{"pubmed":["29757198"],"doi":["10.3390/nano8050322"]}}