biostudies-literatureUnknown8(5)Krajnovic TGerman Academic Exchange Service (DAAD)Ministry of Education, Science and Technological Development of the Republic of SerbiaIn this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. AdditionallNanomaterials (Basel, Switzerland)https://www.ebi.ac.uk/biostudies/studies/S-EPMC5977336biostudies-literatureDrug Delivery System for Emodin Based on Mesoporous Silica SBA-15.PMC597733657219021173013Draca DKaluđerovic GNKrajnovic TMaksimovic-Ivanic DWessjohann LAMijatovic SWolf KEdeler DfalseDrug Delivery System for Emodin Based on Mesoporous Silica SBA-15.In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionall2018-01-01T00:00:00Z2018 May2025-04-21T19:30:57.212Z2019-03-26T23:39:59ZS-EPMC59773362975719810.3390/nano8050322