{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao Y"],"funding":["NIDDK NIH HHS","the Key Project of Natural Science Funds of China","the National Natural Science Foundation of China"],"pagination":["E1011"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5979311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["C-Maf Inducing Protein (<i>CMIP</i>) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between <i>CMIP</i> and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of <i>CMIP</i> rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of <i>CMIP</i> rs2925979_T allele was associated with a 29% higher risk of T2DM in females (<i>p</i> = 9.30 × 10<sup>-4</sup>), while it was not significantly associated with T2DM in male"],"journal":["International journal of molecular sciences"],"pubmed_title":["Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China."],"pmcid":["PMC5979311"],"funding_grant_id":["81230066","81473043","P30 DK020541"],"pubmed_authors":["Hu Y","Cao Y","Wang T","Juan J","Qin X","Wu T","Wu Y","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.","description":"C-Maf Inducing Protein (<i>CMIP</i>) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between <i>CMIP</i> and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of <i>CMIP</i> rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of <i>CMIP</i> rs2925979_T allele was associated with a 29% higher risk of T2DM in females (<i>p</i> = 9.30 × 10<sup>-4</sup>), while it was not significantly associated with T2DM in male","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-05-04T03:30:00.013Z","creation":"2019-03-26T23:40:57Z"},"accession":"S-EPMC5979311","cross_references":{"pubmed":["29597287"],"doi":["10.3390/ijms19041011"]}}