biostudies-literatureCao YNIDDK NIH HHSthe Key Project of Natural Science Funds of Chinathe National Natural Science Foundation of ChinaE1011https://www.ebi.ac.uk/biostudies/studies/S-EPMC5979311biostudies-literatureUnknown19(4)C-Maf Inducing Protein (<i>CMIP</i>) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between <i>CMIP</i> and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of <i>CMIP</i> rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of <i>CMIP</i> rs2925979_T allele was associated with a 29% higher risk of T2DM in females (<i>p</i> = 9.30 × 10^-4), while it was not significantly associated with T2DM in maleInternational journal of molecular sciencesOpposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.PMC59793118123006681473043P30 DK020541Hu YCao YWang TJuan JQin XWu TWu YTang XfalseOpposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.C-Maf Inducing Protein (<i>CMIP</i>) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between <i>CMIP</i> and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of <i>CMIP</i> rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of <i>CMIP</i> rs2925979_T allele was associated with a 29% higher risk of T2DM in females (<i>p</i> = 9.30 × 10^-4), while it was not significantly associated with T2DM in male2018-01-01T00:00:00Z2018 Mar2026-05-04T03:30:00.013Z2019-03-26T23:40:57ZS-EPMC59793112959728710.3390/ijms19041011