biostudies-literatureUnknown9Li T<h4>Introduction</h4><i>Pneumocystis</i> pneumonia (PCP) remains a severe complication with high mortality in immunocompromised patients. It has been well accepted that CD4⁺ T cells play a major role in controlling <i>Pneumocystis</i> infection. Th9 cells were the main source of IL-9 with multifaced roles depending on specific diseases. It is unclear whether IL-9/Th9 contributes to the immune response against PCP. The current study aims to explore the role of IL-9 and the effect of IL-9 on Th17 cells in murine model of PCP.<h4>Materials and methods</h4>Mice were intratracheally injected with 1 × 10⁶<i>Pneumocystis</i> organisms to establish the murine model of <i>Pneumocystis</i> infection. <i>Pneumocystis</i> burden was detected by TaqMan real-time PCR. Using IL-9-deFrontiers in immunology1118https://www.ebi.ac.uk/biostudies/studies/S-EPMC5980981biostudies-literatureIL-9 Deficiency Promotes Pulmonary Th17 Response in Murine Model of <i>Pneumocystis</i> Infection.PMC5980981Li TTong ZHRong HMZhai KZhang CfalseIL-9 Deficiency Promotes Pulmonary Th17 Response in Murine Model of <i>Pneumocystis</i> Infection.<h4>Introduction</h4><i>Pneumocystis</i> pneumonia (PCP) remains a severe complication with high mortality in immunocompromised patients. It has been well accepted that CD4⁺ T cells play a major role in controlling <i>Pneumocystis</i> infection. Th9 cells were the main source of IL-9 with multifaced roles depending on specific diseases. It is unclear whether IL-9/Th9 contributes to the immune response against PCP. The current study aims to explore the role of IL-9 and the effect of IL-9 on Th17 cells in murine model of PCP.<h4>Materials and methods</h4>Mice were intratracheally injected with 1 × 10⁶<i>Pneumocystis</i> organisms to establish the murine model of <i>Pneumocystis</i> infection. <i>Pneumocystis</i> burden was detected by TaqMan real-time PCR. Using IL-9-de2018-01-01T00:00:00Z20182026-04-07T15:30:49.59Z2019-03-26T23:41:15ZS-EPMC59809812988786310.3389/fimmu.2018.01118