biostudies-literatureVulovic BDivision of ChemistryGelest, Inc.University of DelawareResearch Corporation for Science AdvancementDelaware Economic Development OfficeNCRR NIH HHSNIGMS NIH HHS8113-8117https://www.ebi.ac.uk/biostudies/studies/S-EPMC5984048biostudies-literatureUnknown7(12)Using a palladium catalyst supported by DrewPhos, the alkylation of monochlorosilanes with primary and secondary alkyl-magnesium halides is now possible. Arylation with sterically demanding aromatic magnesium halides is also enabled. This transformation overcomes the high bond strength of the Si-Cl bond (113 kcal/mol) and is a rare example of a transition-metal catalyzed process involving its activation. Due to the availability of both chlorosilanes and organomagnesium halide reagents, this method allows for the preparation of a wide range of alkyl and aryl silanes.ACS catalysisPalladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents.PMC5984048CHE-1254360P30 GM11075816A00384P20 GM104316S10 RR026962Vulovic BWatson DACinderella APfalsePalladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents.Using a palladium catalyst supported by DrewPhos, the alkylation of monochlorosilanes with primary and secondary alkyl-magnesium halides is now possible. Arylation with sterically demanding aromatic magnesium halides is also enabled. This transformation overcomes the high bond strength of the Si-Cl bond (113 kcal/mol) and is a rare example of a transition-metal catalyzed process involving its activation. Due to the availability of both chlorosilanes and organomagnesium halide reagents, this method allows for the preparation of a wide range of alkyl and aryl silanes.2017-01-01T00:00:00Z2017 Dec2025-04-04T09:53:50.898Z2019-03-27T00:09:30ZS-EPMC59840482986824410.1021/acscatal.7b03465