biostudies-literatureBasalay MVThe Maurice Hatter FoundationBritish Heart Foundation25https://www.ebi.ac.uk/biostudies/studies/S-EPMC5984640biostudies-literatureUnknown113(4)Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with numerous clinical studies having demonstrated its ability to reduce myocardial infarct size and improve prognosis. On the other hand, there are several clinical trials, in particular those conducted in the setting of elective cardiac surgery, that have failed to show any benefit of RIC. These contradictory data indicate that there is insufficient understanding of the mechanisms underlying RIC. RIC is now known to signal indiscriminately, protecting not only the heart, but also other organs. In particular, experimental studies have demonstrated that it is able to reduce infarct size in an acute ischaemic stroke model. However, the mechanisms underlying RIC-induced neuroprotection are even less well understooBasic research in cardiologyNeural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects.PMC5984640PG/15/52/31598Yellon DMBasalay MVDavidson SMGourine AVfalseNeural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects.Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with numerous clinical studies having demonstrated its ability to reduce myocardial infarct size and improve prognosis. On the other hand, there are several clinical trials, in particular those conducted in the setting of elective cardiac surgery, that have failed to show any benefit of RIC. These contradictory data indicate that there is insufficient understanding of the mechanisms underlying RIC. RIC is now known to signal indiscriminately, protecting not only the heart, but also other organs. In particular, experimental studies have demonstrated that it is able to reduce infarct size in an acute ischaemic stroke model. However, the mechanisms underlying RIC-induced neuroprotection are even less well understoo2018-01-01T00:00:00Z2018 Jun2025-04-19T00:29:23.699Z2019-03-26T23:47:53ZS-EPMC59846402985866410.1007/s00395-018-0684-z