{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Jorgensen SCJ"],"pubmed_abstract":["Delafloxacin (formerly WQ-3034, ABT492, RX-3341) is a novel fluoroquinolone chemically distinct from currently marketed fluoroquinolones with the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions that characterize the infectious milieu at a number of sites. The enhanced potency and penetration in low pH environments contrast what has been observed for other zwitterionic fluoroquinolones, which tend to lose antibacterial potency under acidic conditions, and may be particularly advantageous against methicillin-resistant Staphylococcus aureus, for which the significance of the intracellular mode of survival is increasingly being reco"],"journal":["Infectious diseases and therapy"],"pagination":["197-217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5986682"],"repository":["biostudies-literature"],"pubmed_title":["Delafloxacin: Place in Therapy and Review of Microbiologic, Clinical and Pharmacologic Properties."],"pmcid":["PMC5986682"],"pubmed_authors":["Davis SL","Mercuro NJ","Jorgensen SCJ","Rybak MJ"],"additional_accession":[]},"is_claimable":false,"name":"Delafloxacin: Place in Therapy and Review of Microbiologic, Clinical and Pharmacologic Properties.","description":"Delafloxacin (formerly WQ-3034, ABT492, RX-3341) is a novel fluoroquinolone chemically distinct from currently marketed fluoroquinolones with the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions that characterize the infectious milieu at a number of sites. The enhanced potency and penetration in low pH environments contrast what has been observed for other zwitterionic fluoroquinolones, which tend to lose antibacterial potency under acidic conditions, and may be particularly advantageous against methicillin-resistant Staphylococcus aureus, for which the significance of the intracellular mode of survival is increasingly being reco","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-04T20:42:47.3Z","creation":"2019-03-26T23:41:18Z"},"accession":"S-EPMC5986682","cross_references":{"pubmed":["29605887"],"doi":["10.1007/s40121-018-0198-x"]}}