{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maldonado M"],"funding":["BLRD VA","NIA NIH HHS","McNair Medical Institute","National Cancer Institute","MEDVAMC","NCI NIH HHS","VHA MERIT","National Institute on Aging","American Federation of Aging Research","CSRD VA"],"pagination":["497-504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5989751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Background
Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward.Methods
In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signal that can be measured using functional magnetic resonance imaging) was used to compare three brain regions hypothesized to play a role in C-WL: the hypothalamus (homeostatic), the nucleus"],"journal":["Journal of cachexia, sarcopenia and muscle"],"pubmed_title":["The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study."],"pmcid":["PMC5989751"],"funding_grant_id":["T32AG000183","I01 CX000994","T32 AG000183","I01 CX000174","CX000174","I01 BX002807","I01BX002807","AG040583","3P30CA125123-08S2","P30 CA125123","CX000994","R03 AG040583"],"pubmed_authors":["Viswanath H","Marcelli M","Molfese DL","Garcia JM","Salas R","Hayes TG","Mediwala S","Jones A","Curtis K","Maldonado M","Baldwin P"],"additional_accession":[]},"is_claimable":false,"name":"The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study.","description":"Background
Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward.Methods
In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signal that can be measured using functional magnetic resonance imaging) was used to compare three brain regions hypothesized to play a role in C-WL: the hypothalamus (homeostatic), the nucleus","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-05T13:14:43.461Z","creation":"2019-03-26T23:42:11Z"},"accession":"S-EPMC5989751","cross_references":{"pubmed":["29575771"],"doi":["10.1002/jcsm.12286"]}}