{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bihlmeyer NA"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","Medical Research Council","NHLBI NIH HHS","National Institute for Health Research (NIHR)","NNF Center for Basic Metabolic Research","Lundbeck Foundation","NIGMS NIH HHS"],"pagination":["e001758"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5992491"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest.<h4>Methods and results</h4>We performed an ExomeChip-wide analysis for both QT and JT intervals, including 209 449 variants, both common and rare, in 17 341 genes from the Illumina Infinium HumanExome BeadChip. We identified 10 loci that modulate QT and JT interval duration that have not been previously reported in the literature using single-variant statistical models in a meta-analysis of 95 626 individuals from 23 cohorts (comprised 83 884 European ancestry individuals"],"journal":["Circulation. Genomic and precision medicine"],"pubmed_title":["ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals."],"pmcid":["PMC5992491"],"funding_grant_id":["Hansen Group","R16-2007-1691","UL1 TR001881","R01 HL120393","R01 HL116747","R01 HL111089","NF-SI-0507-10228","T32 GM007814","Pedersen Group","U01 HL120393","Grarup Group","MR/M004422/1","NF-SI-0514-10027","P30 DK063491","R01 HL105756","U01 HL130114","U54 GM115428"],"pubmed_authors":["Psaty BM","Volzke H","Guo X","Soliman EZ","Jukema JW","Sinner MF","Gudnason V","Asselbergs FW","Verweij N","Warren HR","Uitterlinden A","Mook-Kanamori DO","Alonso A","Murray AD","Hayward C","Felix SB","Raitakari OT","Ellinor PT","Kors JA","Nelson CP","Mononen N","Lyytikainen LP","Bihlmeyer NA","Prins BP","Lin H","Huang PL","Tobin MD","Waldenberger M","Huffman JE","Sotoodehnia N","Munroe PB","Li-Gao R","Stricker BHC","Perz S","Smith AV","Lubitz SA","Taylor KD","van Setten J","Newton-Cheh CH","Rivadeneira F","Volker U","Heckbert SR","Dominiczak A","Bis JC","Arking DE","Kooperberg C","Grarup N","Austin T","Peters A","Rotter JI","Kolcic I","Eijgelsheim M","Maan AC","Haessler J","Wilson JG","Spector TD","Marten J","Jamshidi Y","Meitinger T","Radmanesh F","Yao J","Xie Z","Kahonen M","Harrris TB","Kanters JK","Li M","van Duijn CM","de Mutsert R","Samani NJ","Liu CT","Brody JA","Muller-Nurasyid M","Lin HJ","Hall LM","Linneberg A","Dorr M","Polasek O","de Boer RA","Padmanabhan S","van der Meer P","Bots ML","Isaacs A","Mangino M","Weiss S","Perez M","van der Harst P","Lehtimaki T","Rudan I","Pedersen O","Homuth G","Rosand J","Hansen T","Mei H","Kaab S","Launer LJ","Campbell A","Chen YI","van den Berg M","Trompet S","Bork-Jensen J"],"additional_accession":[]},"is_claimable":false,"name":"ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.","description":"<h4>Background</h4>QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest.<h4>Methods and results</h4>We performed an ExomeChip-wide analysis for both QT and JT intervals, including 209 449 variants, both common and rare, in 17 341 genes from the Illumina Infinium HumanExome BeadChip. We identified 10 loci that modulate QT and JT interval duration that have not been previously reported in the literature using single-variant statistical models in a meta-analysis of 95 626 individuals from 23 cohorts (comprised 83 884 European ancestry individuals","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-06-18T04:51:57.974Z","creation":"2019-03-26T22:37:19Z"},"accession":"S-EPMC5992491","cross_references":{"pubmed":["29874175"],"doi":["10.1161/CIRCGEN.117.001758"]}}