{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuchuk O"],"funding":["Italian Ministry of Health","Associazione Italiana Ricerca sul Cancro"],"pagination":["e1445452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5993489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(7)"],"pubmed_abstract":["Interfering with tumor metabolism is an emerging strategy for treating cancers that are resistant to standard therapies. Featuring a rapid proliferation rate and exacerbated glycolysis, hepatocellular carcinoma (HCC) creates a highly hypoxic microenvironment with excessive production of lactic and carbonic acids. These metabolic conditions promote disease aggressiveness and cancer-related immunosuppression. The pH regulatory molecules work as a bridge between tumor cells and their surrounding milieu. Herein, we show that the pH regulatory molecules CAIX, CAXII and V-ATPase are overexpressed in the HCC microenvironment and that interfering with their pathways exerts antitumor activity. Importantly, the V-ATPase complex was expressed by M2-like tumor-associated macrophages. Blocking <i>ex vi"],"journal":["Oncoimmunology"],"pubmed_title":["pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma."],"pmcid":["PMC5993489"],"funding_grant_id":["CC IG-15192","LR IG-14285","52/RF-2010-2312620"],"pubmed_authors":["Huber V","Rivoltini L","Kuchuk O","Villa A","Alison MR","Tuccitto A","Citterio D","Mazzaferro V","Vergani B","Milione M","Carradori S","Castelli C","Camisaschi C","Supuran CT"],"additional_accession":[]},"is_claimable":false,"name":"pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.","description":"Interfering with tumor metabolism is an emerging strategy for treating cancers that are resistant to standard therapies. Featuring a rapid proliferation rate and exacerbated glycolysis, hepatocellular carcinoma (HCC) creates a highly hypoxic microenvironment with excessive production of lactic and carbonic acids. These metabolic conditions promote disease aggressiveness and cancer-related immunosuppression. The pH regulatory molecules work as a bridge between tumor cells and their surrounding milieu. Herein, we show that the pH regulatory molecules CAIX, CAXII and V-ATPase are overexpressed in the HCC microenvironment and that interfering with their pathways exerts antitumor activity. Importantly, the V-ATPase complex was expressed by M2-like tumor-associated macrophages. Blocking <i>ex vi","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-25T21:17:11.814Z","creation":"2019-03-26T23:41:41Z"},"accession":"S-EPMC5993489","cross_references":{"pubmed":["29900055"],"doi":["10.1080/2162402X.2018.1445452"]}}