{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bi G"],"funding":["National Heart, Lung, and Blood Institute","NHLBI NIH HHS","National Institutes of Health"],"pagination":["3583-3596"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5998971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(7)"],"pubmed_abstract":["Although a deficiency of surfactant protein B (SFTPB) has been associated with lung injury, SFTPB expression has not yet been linked with nicotinamide phosphoribosyltransferase (NAMPT), a potential biomarker of acute lung injury (ALI). The effects of Nampt in the pulmonary epithelial cell on both SFTPB expression and lung inflammation were investigated in a LPS-induced ALI mouse model. Pulmonary epithelial cell-specific knockdown of Nampt gene expression, achieved by the crossing of Nampt gene exon 2 floxed mice with mice expressing epithelial-specific transgene Cre or by the use of epithelial-specific expression of anti-Nampt antibody cDNA, significantly attenuated LPS-induced ALI. Knockdown of Nampt expression was accompanied by lower levels of bronchoalveolar lavage (BAL) neutrophil inf"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown."],"pmcid":["PMC5998971"],"funding_grant_id":["R01 HL080042","R01 HL128374","HL080042"],"pubmed_authors":["Bi G","Islam S","Wu L","Easley RB","Huang W","Ye SQ","Li DY","Simon BA","Zhang LQ","Heruth DP","Huang P","Sampath V"],"additional_accession":[]},"is_claimable":false,"name":"Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown.","description":"Although a deficiency of surfactant protein B (SFTPB) has been associated with lung injury, SFTPB expression has not yet been linked with nicotinamide phosphoribosyltransferase (NAMPT), a potential biomarker of acute lung injury (ALI). The effects of Nampt in the pulmonary epithelial cell on both SFTPB expression and lung inflammation were investigated in a LPS-induced ALI mouse model. Pulmonary epithelial cell-specific knockdown of Nampt gene expression, achieved by the crossing of Nampt gene exon 2 floxed mice with mice expressing epithelial-specific transgene Cre or by the use of epithelial-specific expression of anti-Nampt antibody cDNA, significantly attenuated LPS-induced ALI. Knockdown of Nampt expression was accompanied by lower levels of bronchoalveolar lavage (BAL) neutrophil inf","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-05-31T22:20:55.273Z","creation":"2019-07-24T07:21:02Z"},"accession":"S-EPMC5998971","cross_references":{"pubmed":["29452569"],"doi":["10.1096/fj.201701059R","10.1096/fj.201701059r"]}}