biostudies-literatureHernandez-Fuentes MPGuy's and St Thomas' CharityOxford University Hospitals NHS TrustMedical Research CouncilNHS Blood and TransplantNational Institute for Health Research (NIHR)Public Health AgencyWellcome Trust1370-1379https://www.ebi.ac.uk/biostudies/studies/S-EPMC6001640biostudies-literatureUnknown18(6)Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceaseAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsLong- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.PMC6001640STL/3714/07NF-SI-0510-10142MC_PC_15025STL/4760/13G0802068MR/K002996/1WT098051090355/A/09/ZMR/K500999/1R080530NF-SI-0512-10074WT091310G0801537/ID: 88245G0701320G0600698090355/B/09/ZG0600892R090782MR/J006742/1088849/Z/09/ZSheerin NHammad APhelan PSolomon EConlon PFranklin CHiggins RCavalleri GGagliano SAStephens HMacPhee INewstead CWeale MEPowis SThuraisingham RMcKane WTrembath RTopham POpelz GFuggle SJardine ABorrows RGriffin SRowe PUnited Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3Delaney FStapleton CSoranzo NPerucha ELord GMMaxwell PRebollo-Mesa IMcLean AMollon JHernandez-Fuentes MPClarke BMark PBVaughan RLeach TByrne CFeehally JKeogan MSacks SHClatworthy MMarsh JAugustine TfalseLong- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied decease2018-01-01T00:00:00Z2018 Jun2026-05-01T23:29:59.427Z2025-05-29T21:18:26.265ZS-EPMC60016402939289710.1111/ajt.14594