{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Houston C"],"funding":["Rosetrees Trust","British Heart Foundation","National Institute for Health Research (NIHR)","British Heart Foundation Centre of Research Excellence","Imperial College","Academy of Medical Sciences"],"pagination":["155-164"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6004038"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119"],"pubmed_abstract":["Fibrillation is the most common arrhythmia observed in clinical practice. Understanding of the mechanisms underlying its initiation and maintenance remains incomplete. Functional re-entries are potential drivers of the arrhythmia. Two main concepts are still debated, the \"leading circle\" and the \"spiral wave or rotor\" theories. The homogeneous subclone of the HL1 atrial-derived cardiomyocyte cell line, HL1-6, spontaneously exhibits re-entry on a microscopic scale due to its slow conduction velocity and the presence of triggers, making it possible to examine re-entry at the cellular level. We therefore investigated the re-entry cores in cell monolayers through the use of fluorescence optical mapping at high spatiotemporal resolution in order to obtain insights into the mechanisms of re-entr"],"journal":["Journal of molecular and cellular cardiology"],"pubmed_title":["Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line."],"pmcid":["PMC6004038"],"funding_grant_id":["RG/16/3/32175","AMS-SGCL8-Ng","PG/15/59/31621","M577","PG/16/17/32069","RE/13/4/30184","CL-2011-21-001"],"pubmed_authors":["Tzortzis KN","Saglietto A","Pitcher DS","Chowdhury RA","Dupont E","Roney C","Cantwell CD","Ng FS","Peters NS","Houston C"],"additional_accession":[]},"is_claimable":false,"name":"Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line.","description":"Fibrillation is the most common arrhythmia observed in clinical practice. Understanding of the mechanisms underlying its initiation and maintenance remains incomplete. Functional re-entries are potential drivers of the arrhythmia. Two main concepts are still debated, the \"leading circle\" and the \"spiral wave or rotor\" theories. The homogeneous subclone of the HL1 atrial-derived cardiomyocyte cell line, HL1-6, spontaneously exhibits re-entry on a microscopic scale due to its slow conduction velocity and the presence of triggers, making it possible to examine re-entry at the cellular level. We therefore investigated the re-entry cores in cell monolayers through the use of fluorescence optical mapping at high spatiotemporal resolution in order to obtain insights into the mechanisms of re-entr","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-07T00:05:21.591Z","creation":"2019-03-26T23:42:29Z"},"accession":"S-EPMC6004038","cross_references":{"pubmed":["29746849"],"doi":["10.1016/j.yjmcc.2018.05.002"]}}